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HACL2

  • HACL2
  • Protein-coding gene in the species Homo sapiens

    2-hydroxyacyl-CoA lyase 2 is a protein that in humans is encoded by the HACL2 gene. It was originally called ILVBL (ilvB-like) for its similarity to acetolactate

    HACL2

    HACL2

    HACL2

  • Pentadecylic acid
  • Chemical compound

    Mori K, Naganuma T, Kihara A (2023). "Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo". Mol Biol Cell

    Pentadecylic acid

    Pentadecylic acid

    Pentadecylic_acid

  • Alpha oxidation
  • Metabolic pathway

    synthetases (ACSs). 2-OH C16:0-CoA is converted to pentadecanoal (C15:0-CHO) by HACL2 (with HACL1 being able to compensate if knocked out). C15:0-CHO is converted

    Alpha oxidation

    Alpha oxidation

    Alpha_oxidation

  • List of human protein-coding genes 4
  • Q5VWC8 6892 HACE1 HGNC:21033; Q8IYU2 6893 HACL1 HGNC:17856; Q9UJ83 6894 HACL2 HGNC:6041; A1L0T0 6895 HADH HGNC:4799; Q16836 6896 HADHA HGNC:4801; P40939

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • 2-hydroxyacyl-CoA lyase
  • catalyzes reaction (2) and is instead located in the endoplasmic reticulum, HACL2 (gene). This one participates in phytosphingosine degradation. Both the

    2-hydroxyacyl-CoA lyase

    2-hydroxyacyl-CoA_lyase

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