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FOXA1

  • FOXA1
  • Protein found in humans

    protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene. FOXA1 is a member

    FOXA1

    FOXA1

    FOXA1

  • Prostate cancer
  • Male reproductive organ cancer

    that disable SPOP (up to 15% of tumors), and mutations that hyperactivate FOXA1 (up to 5% of tumors). Metastatic prostate cancer tends to have more genetic

    Prostate cancer

    Prostate cancer

    Prostate_cancer

  • Pioneer factor
  • Transcription factor

    factors. In hepatic cell differentiation the activating pioneer factor FOXA1 recruits a repressor, grg3, that prevents transcription until the repressor

    Pioneer factor

    Pioneer_factor

  • Jason Carroll (researcher)
  • British medical researcher

    led to the discovery that FOXA1 is a pioneer factor for ER in breast cancer and subsequent work identified the role of FOXA1 in treatment resistance. He

    Jason Carroll (researcher)

    Jason_Carroll_(researcher)

  • BPIFA4P
  • Pseudogene in the species Homo sapiens

    while the transcription factor FOXA1 activates the expression of BASE/BPIFA4P. The undetermined interplay between ERα and FOXA1 is likely to be important in

    BPIFA4P

    BPIFA4P

    BPIFA4P

  • FOXA2
  • Mammalian protein found in Homo sapiens

    of the Forkhead box (FOX) transcription factors, the other members being FOXA1 and FOXA3. This subfamily of mammalian FOX proteins was first identified

    FOXA2

    FOXA2

    FOXA2

  • Cistrome
  • Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"

    Cistrome

    Cistrome

  • ZNF337
  • Protein-coding gene in the species Homo sapiens

    cancer cell line) Promoter TBP HeLa-S3 (cervical cancer cell line) Promoter FOXA1 HepG2 (human liver cancer cell line) Promoter SIN3A HepG2 (human liver cancer

    ZNF337

    ZNF337

    ZNF337

  • GATA3
  • Protein-coding gene in the species Homo sapiens

    the following transcription factor regulators: ZFPM1 and ZFPM2; LMO1; and FOXA1. These regulators may promote or inhibit GATA3 in stimulating the expression

    GATA3

    GATA3

    GATA3

  • List of human transcription factors
  • ENSG00000075426 bZIP Known motif – High-throughput in vitro [238] TKANTCAYNRTGACGTCAY FOXA1 ENSG00000129514 Forkhead Known motif – High-throughput in vitro [239] BVYTAWGTAAACAAW

    List of human transcription factors

    List_of_human_transcription_factors

  • CELSR1
  • Protein-coding gene in humans

    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542

    CELSR1

    CELSR1

    CELSR1

  • FOXA
  • Topics referred to by the same term

    Corporation, the successor to 21st Century Fox with the same ticker symbol FOXA1, a protein FOXA2, a transcription factor FOXA3, a protein This disambiguation

    FOXA

    FOXA

  • P19 cell
  • Embryonic carcinoma cell line

    H; Huang, X; Yu, L; Meng, X; Chen, Y (Sep 2010). "Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate

    P19 cell

    P19 cell

    P19_cell

  • FOX proteins
  • Family of transcription factors involved in anatomical development

    association with various diseases, including cancer and language disorders. FOXA1, FOXA2, FOXA3 (See also Hepatocyte nuclear factors.) FOXB1, FOXB2 FOXC1

    FOX proteins

    FOX proteins

    FOX_proteins

  • List of intestinal epithelial differentiation genes
  • 90589.2008. PMC 2711760. PMID 19407216. Ye, D. Z.; Kaestner, K. H. (2009). "Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and

    List of intestinal epithelial differentiation genes

    List_of_intestinal_epithelial_differentiation_genes

  • Anduril (workflow engine)
  • Data analysis framework

    S.; Kallioniemi, O.; Hautaniemi, S.; Jänne, O. A. (2011). "Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate

    Anduril (workflow engine)

    Anduril (workflow engine)

    Anduril_(workflow_engine)

  • ASCC2
  • Protein-coding gene in the species Homo sapiens

    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. Stelzl

    ASCC2

    ASCC2

    ASCC2

  • The Cancer Genome Atlas
  • Project to catalogue genetic mutations responsible for cancer

    Lobular Carcinoma 203 Lobular carcinoma distinct from ductal carcinoma; FOXA1 elevated in lobular carcinoma, GATA3 elevated in ductal carcinoma; lobular

    The Cancer Genome Atlas

    The_Cancer_Genome_Atlas

  • Hepatocyte nuclear factors
  • Transcription factors

    contain a winged helix DNA-binding domain and bind to DNA as monomers. HNF3α/FOXA1 (forkhead box A1) HNF3β/FOXA2 (forkhead box A2) HNF3γ/FOXA3 (forkhead box

    Hepatocyte nuclear factors

    Hepatocyte_nuclear_factors

  • James Adjaye
  • Ghanaian-British stem cell Scientist

    Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks., 2016; (contrib.) Induced pluripotent

    James Adjaye

    James_Adjaye

  • Pamela Silver
  • American biologist

    receptor binding reveals long-range regulation requiring the forehead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542

    Pamela Silver

    Pamela_Silver

  • SNAP29
  • Protein-coding gene in the species Homo sapiens

    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. S2CID 16841542

    SNAP29

    SNAP29

    SNAP29

  • ISLR
  • Protein-coding gene in the species Homo sapiens

    factor of activated T-cells Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2) E2F transcription factor 1 Eomesodermin, TBR-2 (T-box, brain, 2)

    ISLR

    ISLR

    ISLR

  • SPOP
  • Protein-coding gene in humans

    MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nature Genetics. 44 (6): 685–9

    SPOP

    SPOP

    SPOP

  • MED12
  • Protein-coding gene in humans

    MA, Garraway LA (Jun 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer" (PDF). Nature Genetics. 44 (6):

    MED12

    MED12

    MED12

  • Transcription factor Sp1
  • Protein-coding gene in the species Homo sapiens

    Yang 1 (YY1)] and negative regulators [GATA2, forkhead box protein A1 (FoxA1), and CCAAT enhancer-binding protein b (C/EBPb)] of FTMT transcription have

    Transcription factor Sp1

    Transcription factor Sp1

    Transcription_factor_Sp1

  • Sulfate transporter
  • Protein-coding gene in the species Homo sapiens

    SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis". Bone. 45 (2): 289–294. doi:10

    Sulfate transporter

    Sulfate transporter

    Sulfate_transporter

  • TOX3
  • Mammalian protein found in Homo sapiens

    breast cancer risk. The risk locus was reported to regulate affinity of FOXA1 binding to chromatin, potentially affecting TOX3 expression. This locus

    TOX3

    TOX3

  • FOXA3
  • Protein-coding gene in the species Homo sapiens

    Bysani MS, et al. (2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq"

    FOXA3

    FOXA3

    FOXA3

  • Chromatin variant
  • M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, et al. (March 2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription"

    Chromatin variant

    Chromatin_variant

  • NK2 homeobox 1
  • Mammalian protein found in Homo sapiens

    deregulation of transcription factors FOXA1/2 (by relaxing histone deacetylation and methylation-mediated repression of Foxa1/2 by Nkx2-1) causing reactivation

    NK2 homeobox 1

    NK2 homeobox 1

    NK2_homeobox_1

  • JARID1B
  • Protein-coding gene in the species Homo sapiens

    affected in many regulators of the development of mammy development such as FOXA1 and estrogen receptor α. However, others have shown that a Jarid1B knockout

    JARID1B

    JARID1B

    JARID1B

  • GATA2
  • Protein found in humans

    early stages of prostate cancer is unclear but may involve the ability of FOXA1 to act indirect to stimulate the expression of the GATA2 gene. The full

    GATA2

    GATA2

    GATA2

  • List of human protein-coding genes 3
  • P53539 5785 FOSL1 HGNC:13718; P15407 5786 FOSL2 HGNC:3798; P15408 5787 FOXA1 HGNC:5021; P55317 5788 FOXA2 HGNC:5022; Q9Y261 5789 FOXA3 HGNC:5023; P55318

    List of human protein-coding genes 3

    List_of_human_protein-coding_genes_3

  • AGR2
  • Protein-coding gene in the species Homo sapiens

    AGR2 in maintaining epithelial barrier function, which is supported by FOXA1 and FOXA2 molecules (transcription factors for epithelial goblet cells)

    AGR2

    AGR2

    AGR2

  • Insulated neighborhood
  • (11 September 2014). "Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus". PLOS Genetics

    Insulated neighborhood

    Insulated neighborhood

    Insulated_neighborhood

  • C20orf27
  • Protein-coding gene in the species Homo sapiens

    region of gene C20orf27 have been discovered, including MITF, JUN, ZNF282, FOXA1, and TCF7L2. Using genomatix, more transcription factor binding sites are

    C20orf27

    C20orf27

    C20orf27

  • MIPOL1
  • Protein-coding gene in the species Homo sapiens

    neighborhood include SLC25A21 (mutation of this gene causes synpolydactyly) and FOXA1. MIPOL1 has at least 15 known splice isoforms produced by alternative splicing

    MIPOL1

    MIPOL1

    MIPOL1

  • Microbubble
  • assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for

    Microbubble

    Microbubble

  • THOC5
  • Protein-coding gene in the species Homo sapiens

    receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. Olsen

    THOC5

    THOC5

    THOC5

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Online names & meanings

  • Nayaab | نایاب
  • Boy/Male

    Muslim

    Nayaab | نایاب

    Rare, Precious

  • Shepperd
  • Surname or Lastname

    English

    Shepperd

    English : variant spelling of Shepherd.

  • Adonikam
  • Biblical

    Adonikam

    the Lord is raised

  • Ishbosheth
  • Boy/Male

    Biblical

    Ishbosheth

    A man of shame.

  • Tychicus
  • Biblical

    Tychicus

    casual; by chance

  • Sanchaya | ஸஂசாயா
  • Girl/Female

    Tamil

    Sanchaya | ஸஂசாயா

    Collection

  • Ghuzayyah
  • Girl/Female

    Indian

    Ghuzayyah

    A narrator of Hadith

  • Alyan
  • Girl/Female

    Arabic, Muslim

    Alyan

    Tall and Healthy

  • CORNELIA
  • Female

    English

    CORNELIA

    Feminine form of Roman Latin Cornelius, CORNELIA means "of a horn." 

  • MIKLÓS
  • Male

    Hungarian

    MIKLÓS

    Hungarian form of Greek Nikolaos, MIKLÓS means "victor of the people." 

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FOXA1

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