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Protein-coding gene in the species Homo sapiens
Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor
FLT4
Lymphedema commonly located in the legs
disease is more common in women and an association with the gene FLT4 has been described. FLT4 codes for VEGFR-3, which is implicated in development of the
Milroy's_disease
Type of congenital heart defect
22q11 deletions also deleting TBX1 gene have been seen in 17% TOF cases. FLT4 gene expression leads to Vascular endothelial growth factor receptor 3 (VEGFR-3)
Tetralogy_of_Fallot
Flt1+/Flt4+ membrane markers identifies an Isl1+/Nkx2.5+ cell population in the developing heart. It was also shown that endogenous Flt1+/Flt4+ cells
Endogenous_cardiac_stem_cell
Growth factor protein found in humans
"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". The EMBO Journal
Vascular endothelial growth factor C
Vascular_endothelial_growth_factor_C
Protein domain
CNTN6, CXADR, DCC, DSCAM, DSCAML1, ESAM, FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5, HMCN1, HNT, HSPG2, ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22
Immunoglobulin_I-set_domain
Protein domain
FCRL2 FCRL3 FCRL4 FCRL5 FCRL6 FCRLA FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FLT1 FLT3 FLT4 FSTL4 FSTL5 GP6 GPA33 GPR116 GPR125 HEPACAM HLA-DMA HLA-DMB HLA-DQB HLA-DQB1
Immunoglobulin_domain
Protein-coding gene in the species Homo sapiens
vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. doi:10.1182/blood.V90.9.3507. PMID 9345034
SHC3
Protein involved in blood vessel growth
VEGF-C and VEGF-D, but not VEGF-A, are ligands for a third receptor (VEGFR-3/Flt4), which mediates lymphangiogenesis. The receptor (VEGFR3) is the site of
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Signaling glycoprotein regulating cell proliferation
"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". EMBO J. 15 (2): 290–298
Platelet-derived growth factor
Platelet-derived_growth_factor
Progressive cystic lung disease
ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proc Natl Acad Sci U S A. 95 (2): 548–553. Bibcode:1998PNAS...95..548A
Lymphangioleiomyomatosis
Protein-coding gene in the species Homo sapiens
and angiogenesis. AGGF1 also interacts with vein specific markers such at flt4, dab2, and ephB4. Ccl2 has also been shown to interact with AGGF1 in hepatocytes
AGGF1
type 1b TYRP1 Tyrosine-related protein 1 Oculocutaneous albinism type 3 FLT4 VEGFR-3 Milroy disease VHL Von Hippel–Lindau disease XPA Xeroderma pigmentosa
List of genes mutated in cutaneous conditions
List_of_genes_mutated_in_cutaneous_conditions
Enzyme
ERBB2; ERBB3; ERBB4; FER; FES; FGFR1; FGFR2; FGFR3; FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2; JAK3;
Tyrosine_kinase
Protein family
fms-related tyrosine kinase 4 Identifiers Symbol FLT4 Alt. symbols VEGFR3, PCL NCBI gene 2324 HGNC 3767 OMIM 136352 RefSeq NM_002020 UniProt P35916 Other
VEGF_receptor
Protein-coding gene in the species Homo sapiens
"Genomic organization of the extracellular coding region of the human FGFR4 and FLT4 genes: evolution of the genes encoding receptor tyrosine kinases with immunoglobulin-like
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Series of molecular signals
exhibit ectopic and persistent expression of the zebrafish ortholog of VEGF3, flt4, within all endothelial cells, while Notch activation completely represses
Notch_signaling_pathway
Part of the development of the lymphatic system, known as lymphangiogenesis
markers such as Vascular endothelial growth factor receptor-3 (Vegfr3 or Flt4; a receptor for VegfC and VegfD), and also the presence of Lyve1, which is
Lymph_sacs
Mammalian protein found in humans
ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National Academy of Sciences of the United States of
C-fos-induced_growth_factor
Protein domain
ERN1 ; ERN2 ; FER ; FES ; FGFR1 ; FGFR2 ; FGFR3 ; FGFR4 ; FGR ; FLT1 ; FLT3 ; FLT4 ; FRK ; FYN ; GAK ; GRK1 ; GRK2 ; GRK3 ; GRK4 ; GRK5 ; GRK6 ; GRK7 ; GSG2 ;
Protein_kinase_domain
Finnish MD and a medical researcher
Aprelikova, O; Pajusola, K; Partanen, J; Armstrong, E; et al. (1992). "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter". Cancer
Kari_Alitalo
Human breast cancer line
ISSN 0344-0338. "ZR-75-1 - CRL-1500 | ATCC". atcc.org. Retrieved 2025-12-10. "Human FLT4 knockout ZR-75-1 cell line - Creative Bioarray". www.cellstrains.com. Retrieved
ZR-75-1
HGNC:3763; P17948 5737 FLT3 HGNC:3765; P36888 5738 FLT3LG HGNC:3766; P49771 5739 FLT4 HGNC:3767; P35916 5740 FLVCR1 HGNC:24682; Q9Y5Y0 5741 FLVCR2 HGNC:20105;
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
German-Finnish biochemist
ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National Academy of Sciences of the United States of
Michael_Jeltsch
pregnancy; 609016; HADHA Hemangioma, capillary infantile, somatic; 602089; FLT4 Hemangioma, capillary infantile, somatic; 602089; KDR Hematopoiesis, cyclic;
List_of_OMIM_disorder_codes
FLT4
FLT4
FLT4
FLT4
Boy/Male
French, German, Greek
Supreme Ruler; All Power
Boy/Male
Hindu
Comely, Loved one
Boy/Male
Indian, Punjabi, Sikh
From God's Word
Boy/Male
British, English
From the Mount of the Rich Man
Boy/Male
American, Australian, British, Celebrity, Chinese, Christian, Danish, Dutch, English, Finnish, French, German, Indian, Latin, Netherlands, Swedish, Swiss
Warlike; From the God Mars; Form of Mark; Defence; Of the Sea
Girl/Female
Indian
Wall
Boy/Male
Welsh
strong fighter'.
Boy/Male
Tamil
Water and earth born
Female
Hebrew
(דּï‹×¨) Variant spelling of Hebrew unisex Dowr, DOR means "generation" or "period of time." In the bible, this is the name of a coastal city in Manasseh, south of Carmel.
Girl/Female
Tamil
Beloved
FLT4
FLT4
FLT4
FLT4
FLT4