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FLT4

  • FLT4
  • Protein-coding gene in the species Homo sapiens

    Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes a tyrosine kinase receptor

    FLT4

    FLT4

    FLT4

  • Milroy's disease
  • Lymphedema commonly located in the legs

    disease is more common in women and an association with the gene FLT4 has been described. FLT4 codes for VEGFR-3, which is implicated in development of the

    Milroy's disease

    Milroy's disease

    Milroy's_disease

  • Tetralogy of Fallot
  • Type of congenital heart defect

    22q11 deletions also deleting TBX1 gene have been seen in 17% TOF cases. FLT4 gene expression leads to Vascular endothelial growth factor receptor 3 (VEGFR-3)

    Tetralogy of Fallot

    Tetralogy of Fallot

    Tetralogy_of_Fallot

  • Endogenous cardiac stem cell
  • Flt1+/Flt4+ membrane markers identifies an Isl1+/Nkx2.5+ cell population in the developing heart. It was also shown that endogenous Flt1+/Flt4+ cells

    Endogenous cardiac stem cell

    Endogenous_cardiac_stem_cell

  • Vascular endothelial growth factor C
  • Growth factor protein found in humans

    "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". The EMBO Journal

    Vascular endothelial growth factor C

    Vascular endothelial growth factor C

    Vascular_endothelial_growth_factor_C

  • Immunoglobulin I-set domain
  • Protein domain

    CNTN6, CXADR, DCC, DSCAM, DSCAML1, ESAM, FGFR1, FGFR3, FGFR4, FGFRL1, FLT1, FLT4, FSTL4, FSTL5, HMCN1, HNT, HSPG2, ICAM5, IGFBP7, IGFBPL1, IGSF10, IGSF22

    Immunoglobulin I-set domain

    Immunoglobulin I-set domain

    Immunoglobulin_I-set_domain

  • Immunoglobulin domain
  • Protein domain

    FCRL2 FCRL3 FCRL4 FCRL5 FCRL6 FCRLA FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FLT1 FLT3 FLT4 FSTL4 FSTL5 GP6 GPA33 GPR116 GPR125 HEPACAM HLA-DMA HLA-DMB HLA-DQB HLA-DQB1

    Immunoglobulin domain

    Immunoglobulin domain

    Immunoglobulin_domain

  • SHC3
  • Protein-coding gene in the species Homo sapiens

    vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. doi:10.1182/blood.V90.9.3507. PMID 9345034

    SHC3

    SHC3

    SHC3

  • Vascular endothelial growth factor
  • Protein involved in blood vessel growth

    VEGF-C and VEGF-D, but not VEGF-A, are ligands for a third receptor (VEGFR-3/Flt4), which mediates lymphangiogenesis. The receptor (VEGFR3) is the site of

    Vascular endothelial growth factor

    Vascular_endothelial_growth_factor

  • Platelet-derived growth factor
  • Signaling glycoprotein regulating cell proliferation

    "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". EMBO J. 15 (2): 290–298

    Platelet-derived growth factor

    Platelet-derived growth factor

    Platelet-derived_growth_factor

  • Lymphangioleiomyomatosis
  • Progressive cystic lung disease

    ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proc Natl Acad Sci U S A. 95 (2): 548–553. Bibcode:1998PNAS...95..548A

    Lymphangioleiomyomatosis

    Lymphangioleiomyomatosis

    Lymphangioleiomyomatosis

  • AGGF1
  • Protein-coding gene in the species Homo sapiens

    and angiogenesis. AGGF1 also interacts with vein specific markers such at flt4, dab2, and ephB4. Ccl2 has also been shown to interact with AGGF1 in hepatocytes

    AGGF1

    AGGF1

    AGGF1

  • List of genes mutated in cutaneous conditions
  • type 1b TYRP1 Tyrosine-related protein 1 Oculocutaneous albinism type 3 FLT4 VEGFR-3 Milroy disease VHL Von Hippel–Lindau disease XPA Xeroderma pigmentosa

    List of genes mutated in cutaneous conditions

    List_of_genes_mutated_in_cutaneous_conditions

  • Tyrosine kinase
  • Enzyme

    ERBB2; ERBB3; ERBB4; FER; FES; FGFR1; FGFR2; FGFR3; FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2; JAK3;

    Tyrosine kinase

    Tyrosine kinase

    Tyrosine_kinase

  • VEGF receptor
  • Protein family

    fms-related tyrosine kinase 4 Identifiers Symbol FLT4 Alt. symbols VEGFR3, PCL NCBI gene 2324 HGNC 3767 OMIM 136352 RefSeq NM_002020 UniProt P35916 Other

    VEGF receptor

    VEGF receptor

    VEGF_receptor

  • Fibroblast growth factor receptor 4
  • Protein-coding gene in the species Homo sapiens

    "Genomic organization of the extracellular coding region of the human FGFR4 and FLT4 genes: evolution of the genes encoding receptor tyrosine kinases with immunoglobulin-like

    Fibroblast growth factor receptor 4

    Fibroblast growth factor receptor 4

    Fibroblast_growth_factor_receptor_4

  • Notch signaling pathway
  • Series of molecular signals

    exhibit ectopic and persistent expression of the zebrafish ortholog of VEGF3, flt4, within all endothelial cells, while Notch activation completely represses

    Notch signaling pathway

    Notch signaling pathway

    Notch_signaling_pathway

  • Lymph sacs
  • Part of the development of the lymphatic system, known as lymphangiogenesis

    markers such as Vascular endothelial growth factor receptor-3 (Vegfr3 or Flt4; a receptor for VegfC and VegfD), and also the presence of Lyve1, which is

    Lymph sacs

    Lymph_sacs

  • C-fos-induced growth factor
  • Mammalian protein found in humans

    ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National Academy of Sciences of the United States of

    C-fos-induced growth factor

    C-fos-induced growth factor

    C-fos-induced_growth_factor

  • Protein kinase domain
  • Protein domain

    ERN1 ; ERN2 ; FER ; FES ; FGFR1 ; FGFR2 ; FGFR3 ; FGFR4 ; FGR ; FLT1 ; FLT3 ; FLT4 ; FRK ; FYN ; GAK ; GRK1 ; GRK2 ; GRK3 ; GRK4 ; GRK5 ; GRK6 ; GRK7 ; GSG2 ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • Kari Alitalo
  • Finnish MD and a medical researcher

    Aprelikova, O; Pajusola, K; Partanen, J; Armstrong, E; et al. (1992). "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter". Cancer

    Kari Alitalo

    Kari Alitalo

    Kari_Alitalo

  • ZR-75-1
  • Human breast cancer line

    ISSN 0344-0338. "ZR-75-1 - CRL-1500 | ATCC". atcc.org. Retrieved 2025-12-10. "Human FLT4 knockout ZR-75-1 cell line - Creative Bioarray". www.cellstrains.com. Retrieved

    ZR-75-1

    ZR-75-1

  • List of human protein-coding genes 3
  • HGNC:3763; P17948 5737 FLT3 HGNC:3765; P36888 5738 FLT3LG HGNC:3766; P49771 5739 FLT4 HGNC:3767; P35916 5740 FLVCR1 HGNC:24682; Q9Y5Y0 5741 FLVCR2 HGNC:20105;

    List of human protein-coding genes 3

    List_of_human_protein-coding_genes_3

  • Michael Jeltsch
  • German-Finnish biochemist

    ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)". Proceedings of the National Academy of Sciences of the United States of

    Michael Jeltsch

    Michael_Jeltsch

  • List of OMIM disorder codes
  • pregnancy; 609016; HADHA Hemangioma, capillary infantile, somatic; 602089; FLT4 Hemangioma, capillary infantile, somatic; 602089; KDR Hematopoiesis, cyclic;

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

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Online names & meanings

  • Pancratius
  • Boy/Male

    French, German, Greek

    Pancratius

    Supreme Ruler; All Power

  • Kevin
  • Boy/Male

    Hindu

    Kevin

    Comely, Loved one

  • Akharee
  • Boy/Male

    Indian, Punjabi, Sikh

    Akharee

    From God's Word

  • Montgomerie
  • Boy/Male

    British, English

    Montgomerie

    From the Mount of the Rich Man

  • Marc
  • Boy/Male

    American, Australian, British, Celebrity, Chinese, Christian, Danish, Dutch, English, Finnish, French, German, Indian, Latin, Netherlands, Swedish, Swiss

    Marc

    Warlike; From the God Mars; Form of Mark; Defence; Of the Sea

  • Nev
  • Girl/Female

    Indian

    Nev

    Wall

  • Gwallter
  • Boy/Male

    Welsh

    Gwallter

    strong fighter'.

  • Kanjak | கஂஜக
  • Boy/Male

    Tamil

    Kanjak | கஂஜக

    Water and earth born

  • DOR
  • Female

    Hebrew

    DOR

    (דּוֹר) Variant spelling of Hebrew unisex Dowr, DOR means "generation" or "period of time." In the bible, this is the name of a coastal city in Manasseh, south of Carmel.

  • Piya | பியா
  • Girl/Female

    Tamil

    Piya | பியா

    Beloved

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