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Blood-clotting protein
Coagulation factor VIII (factor VIII, FVIII, also known as antihemophilic factor A (AHF)) is an essential blood clotting protein. In humans, it is encoded
Factor_VIII
Pharmaceutical drug
Factor VIII, an essential blood coagulation protein, is used as a medication to treat and prevent bleeding in people with hemophilia A and other causes
Factor_VIII_(medication)
Medical condition
a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally
Haemophilia_A
Process of formation of blood clots
best-known coagulation factor disorders are the hemophilias. The three main forms are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency
Coagulation
Genetic disease involving blood clotting
occurs due to low amounts of clotting factor VIII, and haemophilia B, which occurs due to low levels of clotting factor IX. They are typically inherited from
Haemophilia
Mammalian protein involved in blood clotting
important ones are: Factor VIII is bound to VWF while inactive in circulation; factor VIII degrades rapidly when not bound to VWF. Factor VIII is released from
Von_Willebrand_factor
Medical condition
von Willebrand factor (VWF), a protein required for platelet adhesion through the binding to other proteins, particularly factor VIII. The disease is
Von_Willebrand_disease
Contamination of blood products with HIV, Hepatitis B and hepatitis C
haemophilia were principally infected via the plasma-derived product known as factor VIII, a processed pharmaceutical product sourced from the United States and
Infected blood scandal in the United Kingdom
Infected_blood_scandal_in_the_United_Kingdom
Genetic X-linked recessive bleeding disorder
inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). Haemophilia
Haemophilia_B
Monoclonal antibody
episodes in people with hemophilia A (congenital factor VIII deficiency) with or without factor VIII inhibitors. Emicizumab is administered as a subcutaneous
Emicizumab
DNA molecules formed by human agency at a molecular level generating novel DNA sequences
Factor VIII is a blood-clotting protein that is administered to patients with the bleeding disorder hemophilia, who are unable to produce factor VIII
Recombinant_DNA
Gene therapy medication for hemophilia A
made of a virus (AAV5) that has been modified to contain the gene for factor VIII, which is lacking in people with hemophilia A. It is an adeno-associated
Valoctocogene_roxaparvovec
German multinational pharmaceutical and biotechnology company
vitamins, as well as Cutter insect repellent, and Cutter's Factor VIII business. Factor VIII, a clotting agent used to treat hemophilia, was produced,
Bayer
Human disease
against coagulation factor VIII. These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous
Acquired_haemophilia
Blood escaping from the circulatory system
deficiency of Factor VIII causes classic hemophilia A while deficiencies of Factor IX cause "Christmas disease"(hemophilia B). Antibodies to Factor VIII can also
Bleeding
Health crisis in the late 1970s up to 1985
needed] Hemophilia A causes a deficiency in Factor VIII, a protein required for blood clotting. Factor VIII injections are a common treatment to prevent
Contaminated haemophilia blood products
Contaminated_haemophilia_blood_products
Blood product prepared from blood plasma
fibrinogen, Factor VIII, Factor XIII and vWF. In many clinical contexts, use of cryoprecipitate has been replaced with use of clotting factor concentrates
Cryoprecipitate
AIDS spokesperson and poster boy (1971–1990)
As a hemophiliac, White became infected with HIV from a contaminated factor VIII blood treatment and, when diagnosed in December 1984, was given six months
Ryan_White
Medication
Recombinant factor VIIa, which is an activated form of factor VII, bypasses factors VIII and IX and causes coagulation without the need for factors VIII and IX
Recombinant_factor_VIIa
Australian biotechnology company
factor VIII concentrate Berinin P, freeze-dried human coagulation factor IX concentrate Factor X P Behring, a freeze-dried human coagulation factor IX
CSL_Limited
Medication
is a medication used for the treatment of hemophilia A (congenital factor VIII deficiency). Efanesoctocog alfa was approved for medical use in the United
Efanesoctocog_alfa
Type of blood plasma screening test
high titer antibody against factor VIII, try porcine factor VIII, activated prothrombin complex concentrate FEIBA (Factor Eight Inhibitor Bypassing Agent)
Mixing_study
American brothers infected with HIV
who were diagnosed with HIV in 1986 due to HIV-infected infusions of Factor VIII. Their story, especially Ricky Ray's, gained nationwide attention and
Ray_brothers
Abnormality of blood coagulation increasing the risk of blood clotting (thrombosis)
associated with reduced levels of von Willebrand factor — because of increased clearance — and factor VIII, which is related to thrombotic risk . A number
Thrombophilia
Genus of viruses
model of mouse hemophilia is corrected by expressing wild-type platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has
Lentivirus
Medication
of age and older with hemophilia A or hemophilia B, with or without factor VIII or IX inhibitors (neutralizing antibodies). The US Food and Drug Administration
Fitusiran
Medication
A (congenital factor VIII deficiency) without factor VIII inhibitors, or hemophilia B (congenital factor IX deficiency) without factor IX inhibitors.
Marstacimab
Mammalian protein found in Homo sapiens
factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic
Factor_X
Mode of inheritance
clotting disorder caused by a mutation of the Factor VIII gene and leading to a deficiency of Factor VIII. It was once thought to be the "royal disease"
X-linked recessive inheritance
X-linked_recessive_inheritance
Swiss pharmaceutical company
referring to Factor VIII, the blood clotting protein deficient in patients with haemophilia A. Octapharma's inaugural product was the first Factor VIII concentrate
Octapharma
Protein involved in coagulation
into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to
Factor_IX
Test for coagulation of blood
or coagulation factor specific inhibitors), while if it does disappear a factor deficiency is more likely. Deficiencies of factors VIII, IX, XI and XII
Partial_thromboplastin_time
Complex formed by blood clotting factors X and V
Intrinsic tenase complex contains the active factor IX (IXa), its cofactor factor VIII (VIIIa), the substrate (factor X), and they are activated by negatively
Tenase
Evolutionarily-conserved protein domain
domain allows vWF to perform its blood-clotting function by carrying factor VIII around. The D8 domain (amino acids 6-102 in vWF) is a highly structured
Von Willebrand factor type D domain
Von_Willebrand_factor_type_D_domain
Spanish pharmaceutical and chemical manufacturer
consumer protection laws. Grifols is a global supplier of IVIG, albumin, Factor VIII and other plasma-derived products. The therapies Grifols produces include:
Grifols
British haematologist (1946–2021)
monoclonal antibodies, to purify clotting factor VIII. Her work on the purification and characterisation of factor VIII formed part of the scientific developments
Frances_Rotblat
Protein-coding gene in humans
40-kDa huntingtin-associated protein also known as (Coagulation factor VIII associated 1) is a protein that in humans is encoded by the F8A1, F8A2, and
F8A1
Classification of blood types
2001). "The relationship between ABO histo-blood group, factor VIII and von Willebrand factor". Transfusion Medicine. 11 (4): 343–351. doi:10.1046/j.1365-3148
ABO_blood_group_system
Immune disorder leading to increased risk of blood clots
activation pathway factors (factor VIII, factor IX, factor XI and factor XII). Lupus anticoagulant will also rarely cause a factor assay to give a result
Antiphospholipid_syndrome
Medication
release of von Willebrand factor from endothelial cells by acting on the V2 receptor. It also increases endogenous levels of factor VIII, making it useful in
Desmopressin
Pharmaceutical compound
recombinant coagulation factor VIII since it has an amino acid sequence which compares to the 90 + 80 kDa form of factor VIII (BDDrFVIII). It also has
Moroctocog_alfa
Genetic condition involving facial, heart, blood and skeletal features
clotting disorders, partial deficiency of factor VIII:C, partial deficiency of factor XI:C, partial deficiency of factor XII:C, and an imbalance of plasminogen
Noonan_syndrome
Pharmaceutical drug classification
Coagulation factor IX B02BD05 Coagulation factor VII B02BD06 von Willebrand factor and coagulation factor VIII in combination B02BD07 Coagulation factor XIII
ATC_code_B02
Pharmaceutical drug
Turoctocog alfa (trade name NovoEight) is a recombinant antihemophilic factor VIII used for the treatment of and prophylaxis of bleeding patients with haemophilia
Turoctocog_alfa
coagulation: All factors in the coagulation cascade. While the endothelium does produce some factor VIII, the majority of factor VIII is produced in the
Proteins produced and secreted by the liver
Proteins_produced_and_secreted_by_the_liver
Danish healthcare company
cancers), amivantamab (gastric cancer and esophageal cancer), Mim8 (Factor VIII mimetic bi-specific antibody) (Haemophilia A), inclacumab (VOC in Sickle
Genmab
Protein-coding gene in the species Homo sapiens
Willebrand factor and factor VIII from the endothelial cells. Because von Willebrand factor helps stabilize circulating levels of factor VIII, the vasopressin
Vasopressin_receptor_2
Mammalian protein found in Homo sapiens
Factor V and Factor VIII (Factor Va and Factor VIIIa), and one of the amino acids in the bond is serine. These proteins that APC inactivates, Factor Va
Protein_C
Formulary by the World Health Organization
immunoglobulinα Coagulation factor VIII, plasma-derived Coagulation factor IX, plasma-derived Coagulation factor VIII, recombinant Coagulation factor IX, recombinant
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
Medical diagnostic method
sensitive test for detecting lupus anticoagulants. It can also detect factor VIII inhibitors but is sensitive to unfractionated heparin as well. The KCT
Kaolin_clotting_time
2005 American film
transfusions of blood products derived from these plasma products, Factor VIII, died as a result. Factor 8 examines a prison blood-harvesting scheme run by Arkansas
Factor 8: The Arkansas Prison Blood Scandal
Factor_8:_The_Arkansas_Prison_Blood_Scandal
Introduction of foreign genetic material into a host
treatment of deficiencies Factor VIII blood clotting factor Factor IX blood clotting factor Fibrinogen blood clotting factor Lactoferrin as an infant formula
Transgenesis
Belgian molecular biologist and entrepreneur (1947–1992)
the vaccination of foxes, and raccoons), recombinant versions of Factor VIII and Factor IX for the treatment of hemophilia A on behalf of the French blood
Jean-Pierre_Lecocq
Topics referred to by the same term
list of Alboran Sea; see List of NATO country codes A brand name of factor VIII (medication) Y8 (disambiguation) This disambiguation page lists articles
8Y
Medical condition
factor VIII or antihemophilic globulin, hemophilia B with a deficiency in factor IX (Christmas disease), and hemophilia C with a deficiency in factor
Factor_XII_deficiency
Central nervous system disease
Evaluation and (12 April 2019). "Variant Creutzfeldt-Jakob Disease (vCJD) and Factor VIII (pdFVIII) Questions and Answers". FDA. Retrieved 31 March 2022. Lin MT
Neurodegenerative_disease
Blockage of an artery in the lungs
antithrombin levels, and later prothrombin mutation, MTHFR mutation, Factor VIII concentration and rarer inherited coagulation abnormalities. To diagnose
Pulmonary_embolism
Protein domain
domain) is major protein domain of many blood coagulation factors. Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about
Discoidin_domain
Restorationist Christian denomination
Serum Globulins Archived January 6, 2008, at the Wayback Machine and Factor VIII; preparations made from Hemoglobin such as PolyHeme Archived July 23
Jehovah's_Witnesses
Swedish pharmaceutical company
following year to also include the development of a long-lasting recombinant factor VIII Fc fusion protein candidate, rFVIIIFc, for the treatment of hemophilia
Swedish_Orphan_Biovitrum
Mammalian protein found in humans
coagulation factor VIII. The gene spans 70 kb, consists of 25 exons, and the resulting protein has a relative molecular mass of approximately 330kDa. Factor V protein
Factor_V
Addition of a sulfate group to a tyrosine group in a protein
Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor". Journal of Biological Chemistry
Tyrosine_sulfation
American scientist (1919–1975)
factors - The coagulation of the blood, in vitro synthesis of coagulation factors - The coagulation of the blood, antibody inhibitors of factor VIII,
Judith_Graham_Pool
Enzyme involved in blood coagulation in humans
life. In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and XIII to XIIIa. In the
Thrombin
Artificial protein
Soeda T, et al. (October 2012). "A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model". Nature Medicine
Bispecific monoclonal antibody
Bispecific_monoclonal_antibody
Protein-coding gene in the species Homo sapiens
combined deficiency of factor V-factor VIII, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. MCFD2 is
LMAN1
Medication
hemophilia A (congenital factor VIII deficiency) with factor VIII inhibitors; or hemophilia B (congenital factor IX deficiency) with factor IX inhibitors. In
Concizumab
Royal commission of inquiry into the tainted blood scandal in Canada
presence of the antibody associated with HIV. In 1986 and 1987, though Factor VIII concentrate was heat-treated to kill HIV, the treatment was faulty and
Royal Commission of Inquiry on the Blood System in Canada
Royal_Commission_of_Inquiry_on_the_Blood_System_in_Canada
Blood clot (thrombus) that forms within a vein
(type I) Factor V Leiden Prothrombin G20210A Dysfibrinogenemia Non O-blood type Low free protein S Activated protein C resistance High factor VIII levels
Venous_thrombosis
American physician
coagulation. Brinkhous made the seminal discovery of antihemophilic factor (Factor VIII) and showed that it was lacking in hemophiliac patients. His research
Kenneth_Brinkhous
Biopharmaceutical company
Behringwerke introduced Haemate, a human plasma coagulation factor VIII/von Willebrand factor complex, for the treatment of patients with Hemophilia A.
CSL_Behring
Topics referred to by the same term
export version of the Chinese Shenyang J-8 jet interceptor aircraft Factor VIII, a protein F8: an EEG electrode site according to the 10-20 system. Frequency-8
F8
Protein involved in coagulation
activated factor IX and factor VIII. Both pathways lead to the activation of factor X (the common pathway), which combines with activated factor V in the
Tissue_factor
American pharmaceutical company
trials in the United States. The therapy transfers a working copy of the Factor VIII gene into patients who lack one. In Phase II clinical trials, 2 of 7
Spark_Therapeutics
Mammalian protein found in Homo sapiens
include syndecan-1, glycosaminoglycans, von Willebrand factor, and factor VIII-von Willebrand factor complex. OPG has been identified as having a role in
Osteoprotegerin
Pathogen that is transmitted through blood transfusion
high-profile cases such as Ryan White, a haemophiliac who was infected through factor VIII, a blood-derived medicine used to treat the disease. Another person who
Transfusion–transmitted infection
Transfusion–transmitted_infection
Toxicity due to paracetamol overdose
shown that a factor V level less than 10% of normal indicated a poor prognosis (91% mortality), whereas a ratio of factor VIII to factor V of less than
Paracetamol_poisoning
Second daughter of Tsar Nicholas II of Russia(1897–1918)
Imperial Family. The Glorification of the Royal Family Hemophilia A (Factor VIII Deficiency) Coble, Michael D.; Loreille, Odile M.; et al. (11 March 2009)
Grand Duchess Tatiana Nikolaevna of Russia
Grand_Duchess_Tatiana_Nikolaevna_of_Russia
Class of proteins involved in inflammation
leukotrienes, and they also cause the production of platelet-activating factor and IL-6. After stimulation with proinflammatory cytokines, Kupffer cells
Acute-phase_protein
1992 World Wrestling Federation pay-per-view event
WrestleMania VIII was a 1992 professional wrestling pay-per-view (PPV) event produced by the World Wrestling Federation (WWF, now WWE). It was the eighth
WrestleMania_VIII
American physician (1935–2016)
then, was the development of inhibitors to Factor VIII or Factor IX, which neutralized the activity of the factor given for treatment. Prothrombin complex
Jeanne_Lusher
Mammalian protein found in humans
people with hemophilia (with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor.[citation needed] It has also
Factor_VII
for $715 million. Immuno-manufactured blood products including factor VIII and factor IX such as Kryobulin and Krobulin TIM. In 1983, Immuno sued Dr.
Immuno_AG
known for the development of the process allowing the clotting protein Factor VIII to be made to treat hemophilia. Edward Shanbrom was born in West Haven
Edward_Shanbrom
Low temperature dehydration process
groups A and C combined. Therapeutic proteins including antihemophilic factor VIII, interferon alfa, anti-blood clot medicine streptokinase, and wasp venom
Freeze_drying
Species of venomous snake
syndrome), because it is not influenced by deficiencies in clotting factors VIII, IX or XI. Suraj, M.; Narayanan, S.; Srinivasulu, C.; Mohapatra, P.;
Russell's_viper
Danish medical doctor and scientist
same year that HIV infection was caused by commercially manufactured factor VIII based on blood from American donors. The paper was accompanied by an
Mads_Melbye
American biotechnology company
treatment of hemophilia A that aims to transfer a working copy of the Factor VIII gene into patients who lack one. It was approved in the EU in August
BioMarin_Pharmaceutical
Medical technology
December the results of using an adeno-associated virus with blood clotting factor VIII to treat nine haemophilia A patients were published. Six of the seven
Gene_therapy
High tendency to bleed due to a blood clotting disorder
antibodies to coagulation factors, termed inhibitors of coagulation. The main inhibitor is directed against clotting factor VIII. Another example is antiphospholipid
Bleeding_diathesis
American sitcom (1985–1990)
"Wesley's Friend", in which one of Wesley's classmates contracts HIV via factor VIII treatment for hemophilia. The character of Lynn Belvedere was originally
Mr._Belvedere
Method of gene modification
targets the haematopoietic cells in order to increase the amount of factor VIII, which is affected in haemophilia A. But this continues to be a subject
Lentiviral vector in gene therapy
Lentiviral_vector_in_gene_therapy
Mammalian hormone released from the pituitary gland
transcription factors Clock and BMAL1 in order to reduce Per2 protein levels in the cell. At the same time, Per2 also inhibits the transcription factors for the
Vasopressin
Experimental gene therapy
It uses an engineered AAV vector to cause liver cells to produce the Factor VIII blood clotting protein. "Roche loses spark for gene therapy, axing hemophilia
Dirloctogene_samoparvovec
Medical condition
Carcinoembryonic antigen Enolase 2 Autocrine motility factor hPG80 Hemangiosarcoma (endothelium) Factor VIII Digestive Colorectal cancer CA19-9 Carcinoembryonic
Germinoma
Medical condition
proteins but generally do not express CD34, S-100 protein, desmin, trypsin, factor VIII, F4/80, or HLA-DR1 proteins. Uncommonly, the cells in NF tumors express
Nodular_fasciitis
Protein-coding gene in humans
gene. Mutations in MCFD2 cause the combined deficiency of factor V and factor VIII (F5F8D), a recessive bleeding disorder. MCFD2 and ERGIC-53 (or LMAN1)
MCFD2
Medical condition
are two exceptions in this falling tendency: coagulation factor VIII and von Willebrand factor, a platelet adhesive protein. Both inversely rise in the
Liver_disease
Protein complex that coats membrane-bound transport vesicles
combined factor V and factor VIII deficiency. In this disease, the person produces Factor V and VIII but they can not transport factor V or VIII into the
Coatomer
British research scientist in blood coagulation (1919–2003)
concentration and selective extraction of the blood-clotting protein factor VIII. For her research, she would collect the animal blood from local slaughterhouses
Ethel_Bidwell
FACTOR VIII
FACTOR VIII
Male
Spanish
Spanish form of Roman Latin Victor, VÃCTOR means "conqueror."
Surname or Lastname
French and Italian
French and Italian : occupational name from French, northern Italian sartor ‘tailor’ (Latin sartor).English : topographic name denoting someone who lived on land which had been cleared for cultivation, Old French assart, essart ‘woodland cleared for cultivation’ + the habitational suffix -er.
Male
Spanish
Spanish form of Latin Hector, H�CTOR means "defend; hold fast."
Male
Icelandic
Perhaps a modern form of Icelandic Fylkir, FALKOR means "people, tribe."Â
Boy/Male
English American
Doctor; teacher.
Male
English
English surname transferred to forename use, ACTON means "oak tree settlement."Â
Male
English
 Anglicized form of Scottish Gaelic Eachann, HECTOR means "brown horse." Compare with another form of Hector.
Male
Arthurian
, sir Hector de Maris; (defender).
Boy/Male
Latin
Son of Azeus.
Male
Spanish
Spanish name derived from Latin Pastor, PASTOR means "shepherd." St. Pastor was a 9-year-old boy who along with his 13-year-old brother, Justus, was martyred at Alcalá de Henares in the early 4th century.
Male
English
Roman Latin name VICTOR means "conqueror."Â
Male
Greek
(ΚάστωÏ) Greek name KASTOR means "beaver." In mythology, Castor/Kastor and Pollux/Polydeukes ("very sweet") are the twin sons of Leda and are known as the Gemini twins.
Surname or Lastname
English (chiefly Northamptonshire)
English (chiefly Northamptonshire) : probably from the obsolete slang term facer, denoting a braggart or bully. The earliest citation for this term in OED is c. 1515.Americanized spelling of German Feeser.
Male
French
 French and German name derived from Occitan astor, ASTOR means "goshawk," itself from Latin acceptor, a variant of accipiter, meaning "hawk." It was originally a derogatory term for men with hawk-like, predatory characteristics.
Surname or Lastname
Scottish
Scottish : Anglicized form of the Gaelic personal name Eachann (earlier Eachdonn, already confused with Norse Haakon), composed of the elements each ‘horse’ + donn ‘brown’.English : found in Yorkshire and Scotland, where it may derive directly from the medieval personal name. According to medieval legend, Britain derived its name from being founded by Brutus, a Trojan exile, and Hector was occasionally chosen as a personal name, as it was the name of the Trojan king’s eldest son. The classical Greek name, HektÅr, is probably an agent derivative of Greek ekhein ‘to hold back’, ‘hold in check’, hence ‘protector of the city’.German, French, and Dutch : from the personal name (see 2 above). In medieval Germany, this was a fairly popular personal name among the nobility, derived from classical literature. It is a comparatively rare surname in France.
Surname or Lastname
Southern French and German
Southern French and German : from Occitan astor ‘goshawk’ (from Latin acceptor, variant of accipiter ‘hawk’), used as a nickname characterizing a predacious or otherwise hawklike man. The name was taken to southwestern Germany by 17th-century Waldensian refugees from their Alpine valleys above Italian Piedmont.English : variant spelling of Aster.Astor is the name of a famous American family of industrialists and newspaper owners. John Jacob Astor I (1763–1848) was born at Walldorf near Heidelberg, Germany, the son of a butcher. He followed his brother Henry to New York and made a fortune in the fur trade, which was greatly increased by his descendants in industry, hotels, and newspapers. They built the Waldorf-Astoria Hotel in New York. The great-grandson of John Jacob I, William Waldorf Astor (1848–1919), moved to England in 1890, becoming an influential newspaper proprietor and taking British citizenship in 1899. In 1917 he was created Viscount Astor of Hever. His son, the 2nd Viscount (1879–1952), married Nancy Shaw (née Langhorne) (1879–1964), daughter of a VA planter. She became the first woman to sit in the British House of Commons as a member of Parliament.
Male
Greek
(ÎαχώÏ) Greek form of Hebrew Nachowr, NACHOR means "snoring" or "snorting." In the bible, this is the name of the son of Terah and brother of Abraham.
Surname or Lastname
English
English : habitational name from places called Caistor, in Lincolnshire and Norfolk, Caister in Norfolk, or Castor in Cambridgeshire, all named with Old English cæster ‘Roman fort or town’.
Surname or Lastname
English, Portuguese, Galician, Spanish, Catalan, and French
English, Portuguese, Galician, Spanish, Catalan, and French : occupational name for a shepherd, Anglo-Norman French pastre (oblique case pastour), Portuguese, Galician, Spanish, Catalan, pastor ‘shepherd’, from Latin pastor, an agent derivative of pascere ‘to graze’. The religious sense of a spiritual leader was rare in the Middle Ages, and insofar as it occurs at all it seems always to be a conscious metaphor; it is unlikely, therefore, that this sense lies behind any examples of the surname.German and Dutch : humanistic name, a Latinized form of various vernacular names meaning ‘shepherd’, for example Hirt or Schäfer (see Schafer).Americanized spelling of Hungarian Pásztor, an occupational name from pásztor ‘shepherd’.
Surname or Lastname
English
English : habitational name from any of several places, especially in Shropshire and adjacent counties, named Acton. Generally, these are from Old English Äc ‘oak’ + tÅ«n ‘settlement’.
FACTOR VIII
FACTOR VIII
Boy/Male
German, Italian, Spanish
Alphonse; Noble and Eager
Male
Hebrew
(לï‹×—ֵש×) Hebrew name LOCHESH means "whisper." In the bible, this is the name of a Babylonian exile returnee.
Boy/Male
Finnish, Indian, Sanskrit, Swahili
Sea Monster; Blessed
Male
Finnish
Pet form of Finnish Veli, VEIKKO means "brother."
Girl/Female
Tamil
Anantha | அநஂதா, அநஂதயா
Infinite, Endless, Eternal
Boy/Male
Indian, Sanskrit
Overlord of Heaven
Girl/Female
Arabic, Muslim
Scarlet; Ripe
Boy/Male
Tamil
Robbie | ரோபà¯à®ªà¯€Â Â
Abbreviation of robert famed: bright: shining
Boy/Male
German
Powerful ruler.
Boy/Male
Muslim
Sparkle of light, Fire
FACTOR VIII
FACTOR VIII
FACTOR VIII
FACTOR VIII
FACTOR VIII
v. t.
To resolve (a quantity) into its factors.
adv.
In fact; by the act or fact.
v. t.
To confer a doctorate upon; to make a doctor.
n.
A house or place where factors, or commercial agents, reside, to transact business for their employers.
v. i.
Hesitation; trembling; feebleness; an uncertain or broken sound; as, a slight falter in her voice.
n.
See Faitour.
n.
One of the elements, circumstances, or influences which contribute to produce a result; a constituent.
n.
One who transacts business for another; an agent; a substitute; especially, a mercantile agent who buys and sells goods and transacts business for others in commission; a commission merchant or consignee. He may be a home factor or a foreign factor. He may buy and sell in his own name, and he is intrusted with the possession and control of the goods; and in these respects he differs from a broker.
n.
A building, or collection of buildings, appropriated to the manufacture of goods; the place where workmen are employed in fabricating goods, wares, or utensils; a manufactory; as, a cotton factory.
v. t.
To tamper with and arrange for one's own purposes; to falsify; to adulterate; as, to doctor election returns; to doctor whisky.
n.
Any mechanical contrivance intended to remedy a difficulty or serve some purpose in an exigency; as, the doctor of a calico-printing machine, which is a knife to remove superfluous coloring matter; the doctor, or auxiliary engine, called also donkey engine.
pl.
of Factum
n.
A doer or actor; particularly, an evil doer; a scoundrel.
p. pr. & vb. n.
of Factor
n.
A contrivance for removing superfluous ink or coloring matter from a roller. See Doctor, 4.
n.
Same as Fetor.
n.
Same as Radius vector.
n.
The body of factors in any place; as, a chaplain to a British factory.
imp. & p. p.
of Factor