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Chemical compound
with everolimus.[medical citation needed] A phase IIa randomized, placebo-controlled everolimus clinical trial published in 2014 showed that everolimus improved
Everolimus
Class of pharmaceutical drugs
responses were noted. Everolimus is the second novel Rapamycin analog. Compared with the parent compound rapamycin, everolimus is more selective for the
MTOR_inhibitors
Cancer that starts in the kidneys
carcinoma over everolimus in 2015 and was approved by the FDA. Cabozantinib also demonstrated an overall survival benefit over everolimus and was approved
Kidney_cancer
Drug that inhibits activity of immune system
antibodies. It is also active against tumors that are PI3K/AKT/mTOR-dependent. Everolimus is an analog of sirolimus and also is an mTOR inhibitor. Zotarolimus is
Immunosuppressive_drug
Indian multinational biopharmaceutical company
(Nimotuzumab), BLISTO (Glimepiride + Metformin), CANMAb (Trastuzumab), Evertor (Everolimus), TACROGRAF (Tacrolimus), ALZUMAb (Itolizumab) and KRABEVA (Bevacizumab)
Biocon
Stable dispersion of polymer microparticles in an aqueous medium
immunoassay and latex agglutination turbidimetric immunoassay for evaluation of everolimus blood concentrations in renal transplant patients". Journal of Clinical
Latex
Genetic condition causing non-cancerous tumours
Everolimus also showed evidence of effectiveness at treating epilepsy in some people with TSC. In 2017, the European Commission approved everolimus for
Tuberous_sclerosis
Tumors of the nervous or endocrine system within the pancreas
PanNETs by the FDA based on improved progression-free survival (PFS): everolimus (Afinitor) is labeled for treatment of progressive neuroendocrine tumors
Pancreatic neuroendocrine tumor
Pancreatic_neuroendocrine_tumor
Medical study concerned with the kidneys
prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and sirolimus. Newer, so-called "biologic drugs" or monoclonal
Nephrology
Medical condition
to shrink or stabilize subependymal giant cell tumors: rapamycin and everolimus. These both belong to the mTOR inhibitor class of immunosuppressants,
Subependymal giant cell astrocytoma
Subependymal_giant_cell_astrocytoma
Chemical compound
BEZ235/Dactolisib was administered in combination with the mTOR inhibitor Everolimus. The authors concluded that the combination of both drugs demonstrated
Dactolisib
Medical stent that dissolves or is absorbed by the body
"Temporal trends in adverse events after everolimus-eluting bioresorbable vascular scaffold versus everolimus-eluting metallic stent implantation: A meta-analysis
Bioresorbable_stent
Oversight body for the National Health Service in England
was criticism of delays in deciding on a policy for the prescription of Everolimus in the treatment of tuberous sclerosis. Twenty doctors addressed a letter
NHS_England
Chemical compound
US Food and Drug Administration (FDA) approved it (in combination with everolimus) for the treatment of advanced renal cell carcinoma following one prior
Lenvatinib
Progressive cystic lung disease
approach of choice for AMLs that can be managed by less invasive means. Everolimus is approved by the US Food and Drug Administration (FDA) for AML treatment
Lymphangioleiomyomatosis
Pharmaceutical drug
avoided through the use of alternate dosing regimens or analogs such as everolimus or temsirolimus. Pulmonary toxicity, or toxicity to lungs, is a serious
Sirolimus
Type of endocrine gland cancer
amenable to surgical removal and is causing symptoms, targeted therapy with everolimus or sunitinib can reduce symptoms and slow progression of the disease.
Pancreatic_cancer
Medical condition
transplantation and on detection of CAV. Medications including sirolimus and everolimus can slow disease progression. A repeat heart transplantation may be required
Cardiac allograft vasculopathy
Cardiac_allograft_vasculopathy
Cancer that originates in mammary glands
Some respond to a third sequential therapy. Adding an mTOR inhibitor, everolimus, can further slow the tumors' progression. Those with HER2-positive metastatic
Breast_cancer
Medical intervention
FDA-approved drug-eluting stents use sirolimus (also known as rapamycin), everolimus and zotarolimus. Biolimus A9-eluting stents, which utilize biodegradable
Percutaneous coronary intervention
Percutaneous_coronary_intervention
Pharmaceutical compound
vorolanib was approved for use in China. It is used in combination with everolimus for the treatment of advanced renal cell carcinoma in patients who have
Vorolanib
Swiss multinational pharmaceutical corporation
(reserpine/dihydralazine/hydrochlorothiazide) Hypertension Afinitor/Certican/Zortress (everolimus) Prevention of transplant rejection, various cancers 797 2012 80% Amturnide
Novartis
Mammalian protein found in humans
mTOR inhibitors used in the treatment of human cancers, temsirolimus and everolimus. mTOR inhibitors have found use in the treatment of a variety of malignancies
MTOR
Class of medications
1960-11-022 November 1960 1955 1962 ethotoin Peganone 1957-04-2222 April 1957 everolimus Afinitor/Votubia 2009-03-3030 January 2009 felbamate Felbatol 1993-07-2929
Anticonvulsant
Protein complex
These other inhibitors include everolimus and temsirolimus. Compared with the parent compound rapamycin, everolimus is more selective for the mTORC1
MTORC1
Medical condition
Cooper, Caroline Louise; Chadban, Steve (March 14, 2014). "A role for everolimus in post-transplant encapsulating peritoneal sclerosis: First case report"
Encapsulating peritoneal sclerosis
Encapsulating_peritoneal_sclerosis
Tumors of the endocrine and nervous systems
10% in strongly positive SRSS carcinoid tumors. Targeted therapy with everolimus (Afinitor) and sunitinib (Sutent) is approved by the FDA in unresectable
Neuroendocrine_tumor
Branch of pharmacology
Phenobarbital Primidone Digoxin Lidocaine Ciclosporin Tacrolimus Sirolimus Everolimus Mycophenolate Gentamicin Tobramycin Amikacin Vancomycin Bronchodilator
Pharmacokinetics
American biotechnology company
trial of SGN-75 (INN: vorsetuzumab mafodotin) for use in combination with everolimus in patients with renal cell carcinoma 9 October: milestone achievement
Seagen
Chemical compound
PN, Rini BI, Donskov F, et al. (November 2015). "Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma". The New England Journal of Medicine
Cabozantinib
Medical effects of neuroendocrine tumors releasing substances into the blood
effective. In patients who continue to be refractory, mTOR inhibitors such as everolimus. The TPH inhibitor telotristat ethyl may be useful in controlling diarrhea
Carcinoid_syndrome
Pharmaceutical drug classification
Palbociclib L01EF02 Ribociclib L01EF03 Abemaciclib L01EG01 Temsirolimus L01EG02 Everolimus L01EG03 Ridaforolimus L01EG04 Sirolimus L01EH01 Lapatinib L01EH02 Neratinib
ATC_code_L01
Human disease
remove the tumor is the primary treatment method, although imatinib, everolimus, and rapamycin may soon be approved as alternative treatment and management
Stromal_tumor
Type of molecule that may be able to induce death of senescent cells
senomorphics – with candidates such as Apigenin, Rapamycin and rapalog Everolimus – modulate properties of senescent cells without eliminating them, suppressing
Senolytic
Anticancer medication
Clinical trial number NCT01668784 for "Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma
Nivolumab
Form of kidney cancer
years. These treatments are: Nivolumab Axitinib Sunitinib Cabozantinib Everolimus Ipilimumab Lenvatinib Pazopanib Bevacizumab Sorafenib Tivozanib Temsirolimus
Renal_cell_carcinoma
Benign tumor of the kidney
having haemorrhages, 20% of them have life-threatening haemorrhages. Everolimus is US Food and Drug Administration-approved for the treatment of angiomyolipomas
Angiomyolipoma
Medical condition
and tacrolimus, and least with mTOR inhibitors, such as sirolimus and everolimus. The antimetabolites azathioprine and mycophenolic acid have an intermediate
Cutaneous squamous-cell carcinoma
Cutaneous_squamous-cell_carcinoma
Medical implant to treat narrowed arteries
biocompatible or biodegradable coatings, and limus family drugs such as everolimus and zotarolimus. Risks of DES placement include stent thrombosis (approximately
Drug-eluting_stent
Breast cancer medication
postmenopausal women. Interim phase III trial results in 2011 showed that adding everolimus to exemestane therapy against advanced breast cancer can significantly
Exemestane
Concept of extending human lifespan
senescent cells whereas senomorphics – with candidates such as Apigenin, Everolimus and Rapamycin – modulate properties of senescent cells without eliminating
Life_extension
Chemical compound
Lutetium 177-Edotreotide compared to targeted molecular therapy with Everolimus in patients with inoperable, progressive, somatostatin receptor-positive
Edotreotide
Common type of liver cancer
of people with advanced HCC showed no benefit for the combination of everolimus and pasireotide. Hemihypertrophy Oncovirus Portal hypertension Shetty
Hepatocellular_carcinoma
Type of therapy
trial) in non-small-cell lung carcinoma (NSCLC). Temsirolimus (Torisel) Everolimus (Afinitor) Vemurafenib (Zelboraf) Trametinib (Mekinist) Dabrafenib (Tafinlar)
Targeted_therapy
Antibiotic medication
include decreased levels and less effectiveness of antiretroviral agents, everolimus, atorvastatin, rosiglitazone, pioglitazone, celecoxib, clarithromycin
Rifampicin
Type of cancer
the Bcl-2-family member protein Bak. mTOR inhibitors :[citation needed] Everolimus Temsirolimus mTOR is a kinase enzyme inside the cell that regulates cell
Germinal center B-cell like diffuse large B-cell lymphoma
Germinal_center_B-cell_like_diffuse_large_B-cell_lymphoma
Chemical compound
trial number NCT04195750 for "A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)" at ClinicalTrials
Belzutifan
Rare form of a malignant insulinoma involving metastatic growth
Caroli-Bosc FX, Ruszniewski P, Niccoli P, et al. (May 2013). "Efficacy of everolimus in patients with metastatic insulinoma and refractory hypoglycemia". European
Metastatic_insulinoma
Chemical compound
cells were assessed with DOTA-PP-F11N. This treatment in combination with everolimus in mice, resulted in an average size tumor reduction of about 0.3 cm³
Minigastrin
Class of drugs used to treat malignant tumors
mTOR-mediated signal transduction processes. Occasional adverse reactions Everolimus (Afinitor) Vemurafenib Unresectable or metastatic melanoma with BRAF V600E
Antineoplastic
Benign tumor of the vestibulocochlear cranial nerve
challenging. Clinical trials are in progress for other drugs such as everolimus, lapatinib and mifepristone. Common aspirin has been studied as a low-risk
Vestibular_schwannoma
Radiography of heart and blood vessels
with the introduction of drug-eluting stents. Sirolimus, paclitaxel, and everolimus are the three drugs used in coatings which are currently FDA approved
Coronary_catheterization
Medical condition
inhibit cellular signaling by targeting multiple receptor tyrosine kinase. Everolimus and temsirolimus are used in deregulating the mTOR pathway. Specifically
Papillary renal cell carcinoma
Papillary_renal_cell_carcinoma
American cancer researcher
contributed to early and late stage clinical trials of temozolomide, sunitinib, everolimus, and peptide receptor radiotherapy for neuroendocrine tumors. Kulke received
Matthew_Kulke
Medication
(Adipotide) exotoxin against IL-2 (Denileukin diftitox) mTOR inhibitors Everolimus Ridaforolimus Sirolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib
Elranatamab
Facility in Basel, Switzerland
cells and for live imaging in neurons. Description of method of action of everolimus on the mammalian target of rapamycin (mTOR) and provision of rational
Friedrich Miescher Institute for Biomedical Research
Friedrich_Miescher_Institute_for_Biomedical_Research
Indian interventional cardiologist
Karolien De Roeck; Patrick W. Serruys (October 2008). "Systemic exposure of everolimus after stent implantation: A pharmacokinetic study". Am. Heart J. 156 (4):
Ashok_Seth
Medical device and implant company
rapamycin-eluting stent, versus, a sirolimus-eluting stent (SES) and an everolimus-eluting stent (EES) and a bare metal stent (Constant) as a control in
Alvimedica
Medical drug glass
trial number NCT02724020 for "MLN0128 and MLN0128 + MLN1117 Compared With Everolimus in the Treatment of Adults With Advanced or Metastatic Clear-Cell Renal
Phosphoinositide 3-kinase inhibitor
Phosphoinositide_3-kinase_inhibitor
American oncologist and cancer researcher
Evolution of individualized patient care in metastatic kidney cancer. 2008. Everolimus for renal cell carcinoma: predictive factors for response and future directions
Thomas_Hutson
Tumor originating in adipose (fat) tissue
a CDK4 and CDK6 gene inhibitor, in combination with a mTOR inhibitor, everolimus is in a phase II clinical trial in individuals with advanced DDL or leiomyosarcoma
Liposarcoma
Chemical compound
evERA (NCT05306340): A Phase III trial evaluating giredestrant with everolimus in ER+, HER2-negative advanced breast cancer post-CDK4/6 inhibitors. morpheus
Giredestrant
Rejection of transplanted tissue by the recipient's immune system
Anti-proliferatives Azathioprine Mycophenolic acid mTOR inhibitors Sirolimus Everolimus Antibody specific to select immune components can be added to immunosuppressive
Transplant_rejection
Multinational medical technology manufacturer
biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: clinical and angiographic follow-up of the TARGET I trial"
MicroPort
Substance that inhibits the growth of new blood vessels
VEGFR2 tasquinimod Unknown ranibizumab VEGF sorafenib (Nexavar) inhibit kinases sunitinib (Sutent) pazopanib (Votrient) everolimus (Afinitor) dopamine VEGF
Angiogenesis_inhibitor
Eutron evacetrapib (INN) Evalose evatanepag (USAN, INN) Evdi Evenity everolimus (USAN) Evfraxy Evex Evista Evolocumab (INN) Evoxac Evrysdi exagamglogene
List_of_drugs:_Eu–Ez
American-Egyptian physician and academic
Macroglobulinemia". February 16, 2024. "Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia". February 16, 2024. "CXCR4 inhibitor
Irene_Ghobrial
Pharmaceutical drug classification
Seniprutug L04AG18 Sibeprenlimab L04AG19 Axatilimab L04AH01 Sirolimus L04AH02 Everolimus L04AJ01 Eculizumab L04AJ02 Ravulizumab L04AJ03 Pegcetacoplan L04AJ04 Sutimlimab
ATC_code_L04
Monoclonal antibody
(Adipotide) exotoxin against IL-2 (Denileukin diftitox) mTOR inhibitors Everolimus Ridaforolimus Sirolimus Temsirolimus hedgehog inhibitors Glasdegib Sonidegib
Mosunetuzumab
Medical classification system
PARP inhibitors or platinum-based chemotherapy. mTOR inhibitors such as everolimus may show more effect in PIK3CA/Akt e9 mutants than in e20 mutants or wild
Breast_cancer_classification
Type of spreading cancer
PIK3CA gene can lead to hyperactivity and tumor growth. The mTOR inhibitor everolimus has been approved by the FDA. It may be used in combination with the aromatase
Metastatic_breast_cancer
Mammalian protein found in humans
axitinib have been approved by the FDA. The mTOR inhibitor rapamycin analogs everolimus and temsirolimus or VEGF monoclonal antibody bevacizumab may also be an
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
quinomycin B 13602-52-3 C53H72N2O12 atracurium besilate 64228-79-1 C53H83NO14 everolimus 159351-69-6 C53H84NO14P ridaforolimus 572924-54-0 C53H85ClN14O17 syringomycin
List of compounds with carbon numbers 50+
List_of_compounds_with_carbon_numbers_50+
etoposide phosphate – ETS – evaluable disease – evaluable patients – everolimus – Ewing's family of tumors – Ewing's sarcoma – exatecan mesylate – excision
Index_of_oncology_articles
Cells cultured for medical research
signaling pathways in human cancer cells determines their response to everolimus". J. Clin. Invest. 120 (8): 2858–66. doi:10.1172/JCI37539. PMC 2912177
Isogenic_human_disease_models
American medical oncologist
Escudier, Bernard; Powles, Thomas (November 5, 2015). "Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma". The New England Journal of Medicine
Toni_Choueiri
rapamycin; giant cell astrocytomas were treated with the rapamycin derivative everolimus. 2012 A consensus conference was held and revised guidelines for the diagnosis
Timeline of tuberous sclerosis
Timeline_of_tuberous_sclerosis
anomalies, hypothyroidism and GI perforation (uncommon). 2.3 mTOR inhibitors Everolimus PO mTOR inhibitor. Renal cell cancer, pancreatic neuroendocrine tumour
List_of_antineoplastic_agents
Type of radiotherapy
2015). "NeuroEndocrine Tumor Therapy with Lutetium-177-octreotate and Everolimus (NETTLE): A Phase I Study". Cancer Biotherapy and Radiopharmaceuticals
Peptide receptor radionuclide therapy
Peptide_receptor_radionuclide_therapy
Dr U Koul
Premchand R. Kumar; C.G. Bahuleyan (2015). "Paclitaxel-Eluting versus Everolimus-Eluting Coronary Stents in Diabetes". N Engl J Med. 373 (18): 1709–1719
Upendra_Kaul
Greek oncologist, researcher and academic
Melichar, Bohuslav; Venugopal, Balaji (2024-08-22). "Belzutifan versus Everolimus for Advanced Renal-Cell Carcinoma". The New England Journal of Medicine
Stergios_Boussios
Sub-field of genomics
drug everolimus was sequenced, revealing mutations in two genes, TSC1 and NF2. The mutations disregulated mTOR, the protein inhibited by everolimus, allowing
Oncogenomics
Investigational cognition and memory disorder drugs
receptor antagonist [4] CST-2032 – β2-adrenergic receptor agonist [5] Everolimus (Absorb; Absorb BVS; Affinitor; Affinitor Dispersible; Afinitor; Afinitor
List of investigational cognition and memory disorder drugs
List_of_investigational_cognition_and_memory_disorder_drugs
have been done to assess the efficacy of using mTOR inhibitors, such as everolimus or temsirolimus, in ER-positive breast cancers. Some preclinical and clinical
Endocrine therapy resistance in breast cancer
Endocrine_therapy_resistance_in_breast_cancer
signaling pathways in human cancer cells determines their response to everolimus". J. Clin. Invest. 120 (8): 2858–66. doi:10.1172/JCI37539. PMC 2912177
Recombinant AAV mediated genome engineering
Recombinant_AAV_mediated_genome_engineering
Canadian oncologist
fulvestrant and anastrozole or palbociclib and letrozole. Combinations of everolimus and exemestane or palbociclib plus fulvestrant are good second-line therapies
Kathleen_I._Pritchard
beta-methylbutyric acid Hydroxynorketamine Leucine NV-5138 Inhibitors: Rapalogs: Everolimus Ridaforolimus Sirolimus (Rapamycin) Temsirolimus Umirolimus Zotarolimus;
List of signaling peptide/protein receptor modulators
List_of_signaling_peptide/protein_receptor_modulators
Overview of and topical guide to immunology
Upadacitinib Intracellular (reception) IL-1 receptor antagonists Anakinra mTOR Everolimus Ridaforolimus Sirolimus Temsirolimus Umirolimus Zotarolimus Extracellular
Outline_of_immunology
Mammalian protein found in humans
agents, such as sorafenib (VEGFR, PDGFR and RAF kinases inhibitor) and everolimus (mTORC inhibitor) for the treatment of NF1 plexiform neurofibromas, sirolimus
Neurofibromin
American physician
J; Bhor, Menaka; Liu, Zhimei; Dhanda, Rahul; Hutson, Thomas E (2013). "Everolimus vs. Temsirolimus for Advanced Renal Cell Carcinoma: Use and Use of Resources
Nicholas_J._Vogelzang
The new stent used more biocompatible molecules like zotarolimus and everolimus with quicker drug elution. However, despite these improvements, concerns
Dual_therapy_stent
Goudevenos JA, Kounis NG. JACC Cardiovasc Interv 2009; 2: 583–93. Review. Everolimus-eluting versus paclitaxel-eluting stents. Kounis NG, Goudevenos JA. Lancet
Nicholas_Kounis
Austrian pediatric oncologist and metabolism researcher
II Study of Ribociclib in Combination With Topotecan-Temozolomide or Everolimus in Children With Advanced Malignancies". Journal of Clinical Oncology
Raphael_Morscher
EVEROLIMUS
EVEROLIMUS
EVEROLIMUS
EVEROLIMUS
Boy/Male
Hindu, Indian, Tamil
Lord Vishnu
Boy/Male
Tamil
Goddess Parvati, Goddess of desires
Girl/Female
Hindu
Success
Boy/Male
Arabic, Muslim
Lucky; Fortunate
Boy/Male
Indian
Name of a Town
Female
Native American
Native American Omaha name NIDAWI means "fairy."
Boy/Male
Tamil
Akshay Keerti | அகà¯à®·à®¯ கிரà¯à®¤à¯€
Eternal fame
Female
Scottish
Pet form of of Scottish Elspeth, ELSPIE means "God is my oath."
Girl/Female
Greek American English
Pure.
Boy/Male
Hindu, Indian, Punjabi, Sikh
Fame; One who Sings Glories of God
EVEROLIMUS
EVEROLIMUS
EVEROLIMUS
EVEROLIMUS
EVEROLIMUS