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Search references for CDC42. Phrases containing CDC42
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Protein-coding gene in humans
division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell
CDC42
Family of small signalling G proteins
and some plants. Three members of the family have been studied in detail: Cdc42, Rac1, and RhoA. All G proteins are "molecular switches", and Rho proteins
Rho_family_of_GTPases
Protein-coding gene in humans
CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of the serine/threonine protein
CDC42 binding protein kinase beta
CDC42_binding_protein_kinase_beta
Protein-coding gene in humans
CDC42 effector protein 5 is a protein that in humans is encoded by the CDC42EP5 gene. Cell division control protein 42 (CDC42), a small Rho GTPase, regulates
CDC42_effector_protein_5
Small protrusion on a dendrite that receives input from a single axon
of the spine, and actin regulators, small GTPases such as Rac, RhoA, and CDC42, rapidly modify this cytoskeleton. Overactive Rac1 results in consistently
Dendritic_spine
Mammalian protein found in Homo sapiens
human PAK1 was identified as a GTP-dependent interacting partner of Rac1 or Cdc42 in the cytosolic fraction from neutrophils, and its complementary DNA was
PAK1
Mammalian protein found in humans
binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to
Wiskott–Aldrich syndrome protein
Wiskott–Aldrich_syndrome_protein
Type of biological cell polarity
membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust"
Epithelial_polarity
Protein-coding gene in humans
Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing
CDC42EP3
Prevalent tubulovesicular membranes
pathways blocked. CDC42 is a small, Rho family GTPase involved in the pinching off and remodeling of the cellular plasma membrane. CDC42-regulated dynamin
Clathrin-independent endocytosis
Clathrin-independent_endocytosis
Protein-coding gene in humans
as activators of small G-proteins. Dock11 activates the small G protein Cdc42. Dock11 was identified as a protein which is highly expressed in germinal
Dedicator of cytokinesis protein 11
Dedicator_of_cytokinesis_protein_11
Protein-coding gene in the species Homo sapiens
the GTPase Cdc42, a key player in the establishment of cell polarity in all eukaryotic cells. The GEF activity of FGD1, which activates Cdc42, is harbored
FGD1
Prevalent tubulovesicular membranes
and GEECs comprise the Cdc42-mediated CLIC/GEEC endocytic pathway, which is regulated by GRAF1. Each of RhoA, Arf6, or Cdc42 has the capacity to modulate
Clathrin-independent_carrier
family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities
P21-activated_kinases
Protein
receptors integrins α1β1, α3β1, α4β1, α6β1 and Cdc42 GTPase are activated. The activated GTPase then activates Cdc42 which further activates c-Jun kinases and
Laminin_111
Protein-coding gene in humans
development negative regulation of neuron projection development regulation of Cdc42 protein signal transduction positive regulation of MAPK cascade positive
RIT2
Cytotoxin produced by Clostridioides difficile
targets Rho, Rac, and Cdc42. These molecules are important regulators of cell signaling. Small GTPases such as Rho, Rac, and Cdc42 regulate their activity
Clostridioides difficile toxin A
Clostridioides_difficile_toxin_A
Protein-coding gene in the species Homo sapiens
activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator. ARHGAP31 encodes a GTPase-activating protein (GAP)
ARHGAP31
Polar morphology of a cell, a specific orientation of the cell structure
globally by depleting them. The master regulator of polarity in yeast is Cdc42, which is a member of the eukaryotic Ras-homologous Rho-family of GTPases
Cell_polarity
Medical condition
instructions for making a protein that turns on (activates) another protein called CDC42, which transmits signals that are important for various aspects of development
Aarskog–Scott_syndrome
Cellular process
influence other endocytic pathways. When CAV1 binds to Cdc42, CAV1 inactivates it and regulates Cdc42 activity during membrane trafficking events. The process
Endocytosis
Cholesterol-transporting protein most notably implicated in Alzheimer's disease
postsynaptic membrane organization steroid metabolic process regulation of Cdc42 protein signal transduction lipid metabolism negative regulation of amyloid-beta
Apolipoprotein_E
Protein superfamily of small GTPases
expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42". Mol Cell Biol. 10 (11): 5977–82. doi:10.1128/MCB.10.11.5977. ISSN 0270-7306
Ras_superfamily
Topics referred to by the same term
hospital in Novena, Singapore Cell-division cycle in biology cdc20 cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins
CDC_(disambiguation)
Protein-coding gene in the species Homo sapiens
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase
TNK2
Gene and protein involved in Huntington's disease
Holbert S, Dedeoglu A, Humbert S, Saudou F, Ferrante RJ, Néri C (Mar 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological
Huntingtin
Monoamine neurotransmitter
enzymes (GAPDH, mTOR), Rab GTPases (Rab3a, Rab27a), Rho GTPases (RhoA, Rac1, Cdc42), proteins involved in muscle contractility (⍺-actinin, SERCA2a), extracellular
Serotonin
Protein-coding gene in humans
with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". The Journal of Biological Chemistry. 273 (15): 8776–8782. doi:10
RAC1
Protein-coding gene in humans
encoded by the ARHGAP1 gene. ARHGAP1 has been shown to interact with: BNIP2 CDC42, and RHOA. GRCh38: Ensembl release 89: ENSG00000175220 – Ensembl, May 2017
ARHGAP1
Protein-coding gene in the species Homo sapiens
Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene. TRIP10 has been shown to interact with STAT3, Wiskott-Aldrich syndrome
TRIP10
Plant Protein
mammalian cells, plant cells do not contain heterotrimeric G proteins like Cdc42, Rac, and Rho that are known to regulate cellular polarity. ROP proteins
ROP_GTPase
GTPases Rac1 and Cdc42, IQGAP does not actually have GAP function. Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity
IQGAP1
Direct extension and penetration by cancer cells into neighboring tissues
contractions of the actin cytoskeleton under the control of small GTPases Rac1 and Cdc42 with rapid involvement of integrins of the β1 family; 2) occurrence of focal
Invasion_(cancer)
Bacterial infection spread by ticks
signal transduction events resulting in the recruitment of Arp2/3 complex. CDC42, protein tyrosine kinase, phosphoinositide 3-kinase, and Src-family kinases
Rocky_Mountain_spotted_fever
Biological process
cip/kip (p21, p27, p57) P53 p63 p73 family p53 p63 p73 Other Cdc2 Cdc25 Cdc42 Cellular apoptosis susceptibility protein E2F Maturation promoting factor
Cell_division
critical for processes such as endocytosis and cell motility. Activated by Cdc42, a Rho-family small GTPase, WASP/N-WASP activates the Arp2/3 complex, which
Actin assembly-inducing protein
Actin_assembly-inducing_protein
Biological process that adjusts the strength of connections between neurons in the brain
initiates signaling cascades involving Rho family GTPases, primarily RhoA and Cdc42. These pathways regulate actin-binding proteins such as cofilin and profilin
Spike-timing-dependent plasticity
Spike-timing-dependent_plasticity
Series of biochemical reactions
Activating Kinase Akt Phosphorylation Site Details Activated CDC42 kinase 1 (Ack1) Tyr176 Akt binds preferentially to phosphatidic acid (PA) instead of
Akt/PKB_signaling_pathway
Family of proteins that form microfilaments
factor WASp and inhibits CapZ. WASp is also activated by the small GTPase Cdc42, while another nucleation promoting factor WAVE is activated by the GTPase
Actin
False leg found on slime molds, archaea, protozoans, leukocytes and certain bacteria
G protein-coupled receptors, which activate GTPases of the Rho family (e.g. Cdc42, Rac) via G proteins. Rho GTPases are able to activate WASp which in turn
Pseudopodia
Protein family
process of scaffolding formation. Cdc42: This protein is a trafficking regulator a part of the Rho family of GTPases. Cdc42 onitors the protein activity in
Collybistin
Protein-coding gene in humans
(CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and
CDC42BPA
Protein-coding gene in humans
Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene. The product of this gene is a member of the CDC42-binding protein
CDC42EP4
Proteins
contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and guide Drf3 towards the cell cortex where it
Formins
Protein-coding gene in the species Homo sapiens
division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide
PARD3
Rho-type GTPase Cdc42. Specifically, Orb6 kinase spatially restricts Cdc42 activation to be at the polarized tips of a cell, causing the Cdc42-dependent formins
NDR_kinase
Protein-coding gene in the species Homo sapiens
gene. The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP
FNBP1L
Protein-coding gene in the species Homo sapiens
Nelson DL, Stewart DM, Goldenring JR (Jun 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6):
AKAP9
Network of filamentous proteins that forms the internal framework of cells
contractile acto-myosin filaments ("stress fibers"), Rac for lamellipodia and Cdc42 for filopodia. Functions include: Muscle contraction Cell movement Intracellular
Cytoskeleton
Mammalian protein found in Homo sapiens
cDNA library. Like other group I PAKs, PAK3 is stimulated by activated Cdc42 and Rac1. The human PAK3 gene, the longest group I family member, is 283-kb
PAK3
Small signaling G protein
GTPases. TCL (TC10-like) shares 85% and 78% amino acid similarity to TC10 and Cdc42, respectively. TCL mRNA is 2.5 kb long and is mainly expressed in heart
TCL_(GTPase)
Protein family
IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42". Journal of Biological Chemistry. 295 (15). Elsevier BV: 4822–4835. doi:10
IQ motif containing GTPase activating protein
IQ_motif_containing_GTPase_activating_protein
Evolutionary conserved protein domain
conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases. ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12;
RhoGAP_domain
Protein-coding gene in the species Homo sapiens
is encoded by the ARHGDIA gene. ARHGDIA has been shown to interact with: CDC42, RAC1, RHOA, Rac2, and RhoH. GRCh38: Ensembl release 89: ENSG00000141522
ARHGDIA
Spanish biologist, biochemist, inventor (born 1957)
C (15 February 1997). "Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins". Genes & Development. 11 (4): 463–475. doi:10.1101/gad
Juan_Carlos_Lacal
Protein-coding gene in humans
Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene. CDC42, a small Rho GTPase, regulates the formation of F-actin-containing
CDC42EP2
Post-translational modification involving the monoamine serotonin
enzymes (GAPDH, mTOR), Rab GTPases (Rab3a, Rab27a), Rho GTPases (RhoA, Rac1, Cdc42), proteins involved in muscle contractility (⍺-actinin, SERCA2a), extracellular
Serotonylation
Cytotoxin produced by Clostridioides difficile
(Fig. 5), e.g. the Rho family members Rac and Cdc42 by the process of glycosylation of threonine 35 in Cdc42 and Rac, and threonine 37 in Rho. These Rho
Clostridioides difficile toxin B
Clostridioides_difficile_toxin_B
Protein-coding gene in the species Homo sapiens
accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". The Journal of Biological Chemistry. 278 (21): 19220–9. doi:10.1074/jbc
SHANK2
Protein domain
filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 (Rho-family GTPases) and is SH3-independent. The IRSp53/MIM family
IMD_domain
Protein found in humans
protein Cdc42. Dock9 was discovered using an affinity proteomic approach designed to identify novel activators of the small G protein Cdc42 in fibroblasts
Dedicator of cytokinesis protein 9
Dedicator_of_cytokinesis_protein_9
Medical condition
of the Rho family of GTPases and specifically regulate the activity of Cdc42 and Rac1. Autosomal dominant mutations in ARHGAP31 (a GTPase-activating
Adams–Oliver_syndrome
Protein-coding gene in the species Homo sapiens
signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell
T-cell lymphoma invasion and metastasis-inducing protein 1
T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1
Human chromosome
subfamily J, member 2 (17q24.3) ACTG1: actin, gamma 1 (17q25) CDC42EP4: CDC42 effector protein 4 (17q25.1) USH1G: Usher syndrome 1G (autosomal recessive)
Chromosome_17
Reversible biological process
formerly mesenchymal cells that had undergone MET. Two Rho family GTPases – Cdc42 and Rac1 – as well as the transcription factor Paraxis are required for
Mesenchymal–epithelial transition
Mesenchymal–epithelial_transition
Post-translational modification involving the monoamine histamine
protein histaminylation substrates include several G proteins (Gαq, Gαo1, Cdc42), fibrinogen, and the histone proteins H2A, H2B, H3, and H4. In early 2026
Histaminylation
Protein family
mouse models of leukemia. Lymphocyte chemotaxis as a result of Rac and CDC42 activation as well as actin polymerization is believed to be regulated by
G_beta-gamma_complex
Mammalian protein found in Homo sapiens
nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities
PAK4
Actin projection on the leading edge of a migrating cell
and Cdc42 are two Rho-family GTPases which are normally cytosolic but can also be found in the cell membrane under certain conditions. When Cdc42 is activated
Lamellipodium
Neurological process
diffuse out and influence spine growth at nearby sites. The Rho GTPase CDC42 may also contribute to spine clustering by driving long-term spine volume
Neuronal_memory_allocation
American biologist
licensed Paramedic in the State of Michigan since 1998. Adams, A. E., et al. "CDC42 and CDC43, two additional genes involved in budding and the establishment
Barbara_Sloat
Group of signal transduction pathways involved in embryonic development
released. Increased concentrations of calcium and DAG can activate Cdc42 through PKC. Cdc42 is an important regulator of ventral patterning. Increased calcium
Wnt_signaling_pathway
Protein-coding gene in the species Homo sapiens
1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J Biol Chem. 270 (38): 22473–7
RALBP1
Protein found in humans
Paracingulin regulates the activity of Rho family GTPases like RhoA, Rac1 and Cdc42 by interacting with their respective GEFs (guanine nucleotide exchange factor)
Cingulin-like_protein_1
Actin projections on the leading edge of lamellipodia of migrating cells
directed locomotion. Activation of the Rho family of GTPases, particularly Cdc42 and their downstream intermediates, results in the polymerization of actin
Filopodia
P38 mitogen-activated protein kinases
autoinhibition by a smaller ligand (such as Ras for c-Raf, GADD45 for MEKK4 or Cdc42 for MLK3). This commonly (but not always) happens at the cell membrane,
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Protein domain
binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42. The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology"
RhoGEF_domain
Protein-coding gene in the species Homo sapiens
(1997). "MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42". EMBO J. 16 (16): 4961–72. doi:10.1093/emboj/16.16.4961. PMC 1170131. PMID 9305638
MAP3K4
Protein and coding gene in humans
Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S (April 2004). "Cdc42 and mDia3 regulate microtubule attachment to kinetochores". Nature. 428
DIAPH1
Mammalian protein found in Homo sapiens
mediates actin polymerization induced by the small GTP-binding protein Cdc42". Proceedings of the National Academy of Sciences of the United States of
ACTR3
Professor of Cell Biology
University College London, where she identified the role of the GTPase CDC42 and effectors in forming actin-rich filopodial extensions. She investigated
Catherine_Nobes
Mammalian protein found in humans
these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing
WASL_(gene)
Protein-coding gene in the species Homo sapiens
functions to enhance the GTPase activity of the Rho-GTPase proteins RhoA and Cdc42, promoting the hydrolysis of their bound GTP to GDP and thus “shutting off”
DLC1
Protein-coding gene in humans
Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene. CDC42 is a member of the Rho GTPase family that regulates multiple
CDC42EP1
Protein-coding gene in humans
PMID 9668039. Ikeda W, Nakanishi H, Tanaka Y, et al. (2001). "Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin
FGD4
Protein and coding gene in humans
to interact with syntaxin13 and activated Cdc42. The interaction with Cdc42 inhibit the activity of Cdc42 to remodel dendritic spine structure. Homer1a
HOMER1
Protein-coding gene in the species Homo sapiens
encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved
PARD6A
Protein-coding gene in the species Homo sapiens
its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor
SNX9
Protein-coding gene in humans
terminally truncated isoform version which selectively activates Rac1 and Cdc42 to perform functions. p63RhoGEF is the full length isoform which contains
GEFT
Protein-coding gene in the species Homo sapiens
dangerous one as it promotes colorectal cancer development by regulating Cdc42 interacting protein. C1orf94 evolved faster than both Cytochrome C and less
C1orf94
Biological process
downstream effectors. VopS also adenylates RhoA and cell division cycle 42 (CDC42), leading to a disaggregation of the actin filament network. As a result
Adenylylation
Series of chemical reactions resulting in a cell response
proteins. For adhesion to the extracellular matrix, ILK activate the Rac and Cdc42 proteins and leading to actin polymerization. ERK also leads to actin polymerization
Biochemical_cascade
Protein-coding gene in humans
exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1". The Journal of Biological Chemistry. 275 (38): 29788–29793
KRAS
Protein-coding gene in the species Homo sapiens
1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase". Mol. Cell. Biol. 16 (6): 3169–78
ARHGAP26
Protein-coding gene in the species Homo sapiens
characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42". Oncogene. 26 (55): 7620–267. doi:10.1038/sj.onc.1210574. PMID 17599059
Spermatogenesis_associated_13
Protein-coding gene in the species Homo sapiens
cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8). ENGLAND: 531–9. doi:10.1038/35019573. ISSN 1465-7392
RHOQ
Protein-coding gene in the species Homo sapiens
Deki Y, Yagisawa H (Dec 2007). "START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology". Biochemical
STARD8
G protein
gene. RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution. Tao W
Wrch1
Eye structure
Timothy F. (April 2016). "Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition". Developmental Biology. 412
Lens_(vertebrate_anatomy)
Transmembrane protein on the surface of a B cell
domain is Bam32. This recruits and activates small GTPases such as Rac1 and Cdc42. These, in turn, are responsible for the cytoskeletal changes associated
B-cell_receptor
CDC42
CDC42
CDC42
CDC42
Surname or Lastname
English
English : topographic name from Middle English stille ‘calm’, ‘quiet’, + welle ‘spring’, ‘stream’, or possibly a habitational name from a minor place, now lost, of which the first element may have been Old English stigel, stigol ‘stile’, ‘steep place’.
Girl/Female
Arabic, Muslim
Opening
Boy/Male
Indian, Punjabi, Sikh
Master of Yoga
Boy/Male
Afghan, African, Arabic, Australian, French, Iranian
Owner
Boy/Male
Hindu, Indian, Marathi
Request
Boy/Male
Hindu
Lord Ganesh
Female
Native American
Native American Indian name ALAMEDA means "grove of cottonwood."
Girl/Female
English
Abbreviation of Virginia.
Boy/Male
Arabic, Muslim
Concealed; Hidden
Boy/Male
Indian
Rock Art
CDC42
CDC42
CDC42
CDC42
CDC42