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Chemical compound
Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative
Aprepitant
Chemical compound class
associated with cancer chemotherapy. An example of a drug in this class is aprepitant. Chemotherapy-induced emesis appears to consist of acute and delayed phases
NK1_receptor_antagonist
Chemical compound (polypeptide neurotransmitter)
termed: SP antagonists, or tachykinin antagonists.) One such drug is aprepitant to prevent the nausea and vomiting that accompanies chemotherapy, typically
Substance_P
Medication administered into a vein
discharged if they still require IV therapy. Some medications, such as aprepitant, are chemically modified to be better suited for IV administration, forming
Intravenous_therapy
Chemical compound
antiemetic medication, administered intravenously. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved for medical
Fosaprepitant
InterPro Family
receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant. The genes and receptor ligands are as follows: (Hökfelt et al., 2001;
Tachykinin_receptor
Atypical antipsychotic medication
vomiting (CINV). In general, olanzapine appears to be about as effective as aprepitant for the prevention of CINV, though some concerns remain about its use
Olanzapine
Common side effects in chemotherapy treatment
tomography (PET) studies have shown that aprepitant can penetrate the brain and NK1 receptors in the brain. Aprepitant has also been shown to increase the
Chemotherapy-induced nausea and vomiting
Chemotherapy-induced_nausea_and_vomiting
Chemical compound
fluoxetine, mefloquine, leflunomide, nulitamide, dutasteride, bicalutamide, aprepitant, celecoxib, fipronil, fluazinam, penthiopyrad, picoxystrobin, fluridone
Trifluoromethylation
Cholesterol-lowering medication
and only rarely with other CYP3A4 inhibitors, such as amiodarone and aprepitant. Often, bosentan, fosphenytoin, and phenytoin, which are CYP3A4 inducers
Atorvastatin
Drug used to prevent nausea or vomiting
only used in the context of chemotherapy induced nausea and vomiting. Aprepitant (Emend) is a commercially available NK1 receptor antagonist Casopitant
Antiemetic
Chemical compound
been used in the synthesis of commercial drugs such as ezetimibe and aprepitant. CBS catalyst Corey-Itsuno reduction "(R)-2-Methyl-CBS-oxazaborolidine"
(R)-2-Methyl-CBS-oxazaborolidine
(R)-2-Methyl-CBS-oxazaborolidine
drugs to block growth factors that enhance or drive glioblastoma growth — aprepitant blocks NK-1, auranofin inhibits thioredoxin reductase, captopril inhibits
CUSP9
Protein-coding gene in the species Homo sapiens
been studied in migraine, emesis, and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of
Tachykinin_receptor_1
Chemotherapy medication
antagonist (e.g., ondansetron) and/or NK1 receptor antagonist (e.g., aprepitant). Other significant side effects include headache, fatigue and occasionally
Dacarbazine
Abnormally increased sensitivity to pain
Schmelz M, Koppert W (February 2007). "Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model
Hyperalgesia
Medical condition
corticosteroids (dexamethasone), and neurokinin-1 receptor antagonists (aprepitant) primarily act by modifying the release and activity of the aforementioned
Postoperative nausea and vomiting
Postoperative_nausea_and_vomiting
Sulfamethoxazole Sulfaphenazole Teniposide Valproic acid Voriconazole Zafirlukast Aprepitant Bosentan Carbamazepine Enzalutamide Phenobarbital Phenytoin Rifampicin
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
Pharmaceutical drug
most other 5HT3 antagonists, data is lacking for use of dolasetron with aprepitant in chemotherapy-induced nausea and vomiting (CINV). It is also sometimes
Dolasetron
Chemical compound
and as a treatment for tinnitus and insomnia. NK1 receptor antagonist Aprepitant Casopitant Fosaprepitant L-733,060 Maropitant "International Nonproprietary
Vestipitant
Chemical compound and pharmaceutical drug
(ondansetron, granisetron, etc.) in combination with corticosteroids. Aprepitant combined with ondansetron and dexamethasone has been shown to be better
Cisplatin
Enzyme that metabolizes substances by oxidation
rilpivirine; albendazole (antihelminthic) cisapride, (5-HT4 receptor agonist) aprepitant, (antiemetic) caffeine, (stimulant) cocaine, (stimulant) cilostazol, (phosphodiesterase
CYP3A4
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Fezolinetant
Medication used to treat insomnia
(concomitant use not recommended); the moderate CYP3A4 inhibitors amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, dronedarone, erythromycin, fluconazole
Daridorexant
Veterinary medication
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Maropitant
List of pharmaceutical drugs under clinical development for treatment of depression
actions Amibegron (SR-58611; SR-58611A) – β3-adrenergic receptor agonist Aprepitant (MK-869) – neurokinin NK1 receptor antagonist ARA-014418 (AR-A014418;
List of investigational antidepressants
List_of_investigational_antidepressants
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Elinzanetant
Anti-nausea group of medications
The concomitant administration of a NK1 receptor antagonist, such as aprepitant, significantly increases the efficacy of 5-HT3 antagonists in preventing
5-HT3_antagonist
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Tradipitant
Biochemistry method
microtubule-targeting agents (MTAs), including clinically used drugs such as aprepitant, disulfiram, and toremifene, by directly demonstrating their interaction
Nano differential scanning fluorimetry
Nano_differential_scanning_fluorimetry
Medical intervention
symptoms. Improved antiemetics such as ondansetron and analogues, as well as aprepitant have made aggressive treatments much more feasible in cancer patients
Cancer_treatment
Medication used to treat insomnia
(concomitant use not recommended); the moderate CYP3A4 inhibitors amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, dronedarone, erythromycin, fluconazole
Suvorexant
finasteride Proscar Benign prostatic hyperplasia (enlarged prostate) Merck aprepitant Emend Nausea and vomiting prevention caused by chemotherapy Merck olanzapine
Annual pharmaceutical drug sales
Annual_pharmaceutical_drug_sales
Investigational anxiety disorder drugs
inhibitor (SDRI) [68] AP-521 – serotonin 5-HT1A receptor partial agonist [69] Aprepitant (Emend; L-754030; MK-0869; MK-869; ONO-7436) – neurokinin NK1 receptor
List of investigational anxiety disorder drugs
List_of_investigational_anxiety_disorder_drugs
Medical symptom
three-drug regimen including a 5-HT3 receptor antagonist, dexamethasone and aprepitant (a neurokinin-1 antagonist) given before chemotherapy. A common consequence
Cancer_and_nausea
Investigational Parkinson's disease drugs
receptor agonist and other actions [21] Aprepitant/pramipexole (ALTO-208; CTC-413) – combination of aprepitant (neurokinin NK1 receptor antagonist) and
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Chemical compound
significantly longer than that of the first NK1 receptor antagonist, aprepitant, which has a half-life of 9 to 13 hours. "Akynzeo- netupitant and palonosetron
Netupitant
Chemical compound
medications or therapies that can impact patient safety and treatment efficacy. Aprepitant, a drug that prevents nausea and vomiting that may occur during chemotherapy
Thiotepa
Protein family
and veterinary medicine. Examples of tachykinin antagonists include: Aprepitant Casopitant Fosaprepitant Maropitant Nepadutant Osanetant Saredutant Talnetant
Tachykinin_peptides
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Neurokinin_A
Pharmaceutical drug classification
Chlorobutanol A04AD05 Metopimazine A04AD10 Dronabinol A04AD11 Nabilone A04AD12 Aprepitant A04AD13 Casopitant A04AD14 Rolapitant A04AD51 Scopolamine, combinations
ATC_code_A04
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Pavinetant
Enzyme protein
resveratrol (a plant-based stilbenoid) Strong rifampicin (bactericidal) secobarbital (barbiturate) Weak aprepitant bosentan phenobarbital St Johns Wort
CYP2C9
Pharmaceutical drug
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Rolapitant
strategy has led to the development of receptor-specific compounds, such as aprepitant (MK 869), a neurokinin-1 receptor antagonist used in treating chemotherapy-induced
Insect_neuropeptide
American honorary association founded in 1987
Mills 2013 Discoveries in cancer research and most notably the substance Aprepitant, which has had worldwide impact in patient compliance/tolerance for chemotherapy
New Jersey Inventors Hall of Fame
New_Jersey_Inventors_Hall_of_Fame
Chemical compound
dexamethasone and ondansetron or triplex dexamethasone, ondansetron and aprepitant. Ototoxicity: Nedaplatin is toxic to the nerve and hair cells in the cochlea
Nedaplatin
Pharmaceutical drug
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Netupitant/palonosetron
American chemist and structural biologist
Zhao. “Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography” Nat Commun 10, 638 (2019). doi: 10.1038/s41467-019-08568-5
Raymond_C._Stevens
Professor of medical oncology
development and subsequent FDA and EMA approval of the NK1 antagonist aprepitant NK1 receptor antagonist. His research highlighted that when 5HT3 and NK1
Ronald_de_Wit
Investigational antipsychotics
SLS-006; WAY-DAB 452) – dopamine D2 receptor agonist – schizophrenia [138] Aprepitant (Emend; L-754030; MK-0869; MK-869; ONO-7436) – neurokinin NK1 receptor
List of investigational antipsychotics
List_of_investigational_antipsychotics
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Osanetant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Casopitant
apraclonidine (INN) apramycin (INN) apratastat (USAN, INN) apremilast (USAN, INN) aprepitant Apresazide Apresoline-Esidrix Apresoline Apretude Apri apricitabine (INN)
List_of_drugs:_An–Ap
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Orvepitant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Vofopitant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Neurokinin_B
Reduction of average diameter of a solid's particles
products, including sirolimus (Rapamune oral tablet, approved 2000), aprepitant (Emend, 2003), fenofibrate (Tricor 145 mg, 2004; Triglide, 2005), and
Micronization
Protein-coding gene in the species Homo sapiens
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Tachykinin_receptor_2
Chemical compound
anticancer effects in a variety of in vitro models. NK1 receptor antagonists Aprepitant Casopitant Fosaprepitant Maropitant Vestipitant Vofopitant Seabrook GR
L-733,060
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Lanepitant
Protein-coding gene in the species Homo sapiens
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Tachykinin_receptor_3
British physiologist (born 1953)
receptor antagonists have been approved for human clinical use including aprepitant which is sold under the brand name Emend. Clinical reviews indicate selective
Paul_Andrews_(scientist)
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Talnetant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Ibodutant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Burapitant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Saredutant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Serlopitant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
GR-159897
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Befetupitant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Nepadutant
Chemical compound
Neurokinin receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721
Ezlopitant
APREPITANT
APREPITANT
APREPITANT
APREPITANT
Girl/Female
Hindu, Indian, Tamil
Pure
Surname or Lastname
English
English : habitational name from any of various places, for example in Cheshire and Derbyshire, so named from Old English hÅh ‘spur of a hill’ (literally ‘heel’). This widespread surname is especially common in Lancashire.Irish (County Limerick) : variant of Haugh 1.
Girl/Female
Hindu, Indian
Peaceful
Male
Norwegian
Norwegian form of Old Norse Oddr, ODD means "point of a weapon."
Boy/Male
Muslim
Increase
Boy/Male
Bengali, Hindu, Indian
Everyday
Girl/Female
Hindu
Girl/Female
Tamil
Swayambhi | ஸà¯à®µà®¯à®¾à®®à¯à®ªà¯€
Independent
Male
French
Masculine form of French Aimée, AIMÉ means "much loved."
Girl/Female
Latin
Flower name.
APREPITANT
APREPITANT
APREPITANT
APREPITANT
APREPITANT