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See searches and references containing AIM2!AIM2
Protein-coding gene in the species Homo sapiens
Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a cytoplasmic
AIM2
Cytosolic multiprotein complex that mediates the activation of Caspase 1
(nucleotide-binding oligomerization domain and leucine-rich repeat-containing receptors), AIM2 (absent in melanoma 2), IFI16 (IFN-inducible protein 16), and pyrin. Through
Inflammasome
Inherited retrovirus encoded in an organism's genome
binding site for AIM2, meaning that it is necessary for the transcription of AIM2. Researchers had shown this by deleting MER41.AIM2 in HeLa cells using
Endogenous_retrovirus
Protein domain
in melanoma 2-like (AIM2-like) receptors function as recognition of foreign double-stranded DNA. Two ALRs with pyrin domains, AIM2 and IFI16, assemble
Pyrin_domain
Type of programmed cell death
PAMPs and DAMPs stimuli. Some non-NLR proteins like absent in melanoma 2 (AIM2) and pyrin can also be activated and form inflammasomes. Also, non-inflammasome-forming
Pyroptosis
Inflammatory cell death pathway
conditions, and cancer. Several PANoptosome complexes, such as the ZBP1-, AIM2-, RIPK1-, NLRP3 and NLRC5- and NLRP12-PANoptosomes, have been characterized
PANoptosis
Protein domain
mediators of Caspase-1 activation are: NOD-like Leucine Rich Repeats (NLRs), AIM2-Like Receptors (ALRs), Pyrin and IFI16. These proteins allow caspase-1 activation
Caspase
LTR ERVs in primates
enhancer for nearby interferon-stimulated genes. MER41.AIM2 is located 220 bp upstream of the AIM2 transcription start site, which provides the only STAT1
MER41
Biological cell ceasing to carry out its functions
several PANoptosome complexes have been characterized, including ZBP1-, AIM2-, RIPK1-, NLRC5-/NLRP12-, and NLRP3-PANoptosomes. PANoptosis is critical
Cell_death
cytosolic DNA sensing via STING can lead to NLRP3 inflammasome activation (with AIM2 being dispensable in that context). His research has translational relevance
Veit_Hornung
Indian immunologist
identified several critical innate immune sensors—including NLRP3, ZBP1, AIM2, NLRC5, and NLRP12 —that drive inflammatory cell death, and defined their
Thirumala-Devi_Kanneganti
American microbiologist
Esparo NM, Child SJ, Geballe AP PLOS Pathogens. 2016 Oct; 12 10: e1005966 The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular
Adam_Geballe
Protein domain
et al. (May 2015). "Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida". Nature Immunology
Guanylate-binding_protein
A signalling complex involved in necrotic cell death. Inflammasomes: The AIM2 and NLRP3 inflammasomes are filamentous assemblies that elicit host defense
Signalosome
Levine, R. L.; Reilly, M. P.; Libby, P.; Wang, N.; Tall, A. R. (2021). "The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis". Nature
Leducq_Foundation
Type of molecules within cells
TLR2, TLR4, RAGE HMGN1 TLR4 IL-1α IL-1R IL-33 ST2 SAP130 Mincle DNA TLR9, AIM2 RNA TLR3, TLR7, TLR8, RIG-I, MDA5 Mitochondria mtDNA TLR9 TFAM RAGE Formyl
Damage-associated molecular pattern
Damage-associated_molecular_pattern
Protein-coding gene in the species Homo sapiens
is also a key component of the absent in melanoma 2 (AIM2)-PANoptosome, which includes the AIM2 inflammasome, and assembles in response to Francisella
ZBP1
Protein-coding gene in humans
receptors, c) RIG-I-like receptors, d) AIM2 (also termed absent in melanoma 2 or interferon-inducible protein AIM2), and e) C-type lectin receptors (i.e
CLEC1B
Medical condition
(interleukin-1β, interleukin 1 RN, CASP1, interleukin 18 RAP) and interferon induced (AIM2, IP-10/CXCL10) genes. T cell associated genes (CD3, CD8B) are down regulated
Periodic fever, aphthous stomatitis, pharyngitis and adenitis
Periodic_fever,_aphthous_stomatitis,_pharyngitis_and_adenitis
Blood vessel lining
well as the high expression of inflammasome molecules NLRP-1, NLRP-3, and AIM2 point to innate immune functions of LSECs. In addition, LSECs display features
Liver sinusoidal endothelial cell
Liver_sinusoidal_endothelial_cell
Any type of cell death eliciting an immune response
by some members of Nod-like receptor family (NLRs), absent in melanoma 2 (AIM2) or pyrin leads to the assembly of an inflammasome structure and caspase
Immunogenic_cell_death
Irish-born American molecular biologist and virologist
Gabor; Caffrey, Daniel. R.; Latz, Eicke; Fitzgerald, Katherine A. (2009). "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome
Katherine_A._Fitzgerald
Protein family
different eukaryotic organisms including mentioned above human factors: AIM1, AIM2, and AIM3 (Xie et al., 2005), yeast factors NDI1 and AIF1 as well as AIF
Apoptosis-inducing_factor
Human protein and coding gene
component cytoplasm NLRP3 inflammasome complex NLRP1 inflammasome complex AIM2 inflammasome complex nucleolus endoplasmic reticulum mitochondrion IkappaB
PYCARD
Enzyme found in humans
complex cytoplasm endoplasmic reticulum membrane membrane extracellular region AIM2 inflammasome complex IPAF inflammasome complex endoplasmic reticulum mitochondrion
Caspase_4
Protein found in humans
apoptotic signaling pathway Cellular component NLRP3 inflammasome complex AIM2 inflammasome complex IPAF inflammasome complex endoplasmic reticulum cytoplasm
Caspase_12
HGNC:21411; Q9BRQ8 475 AIFM3 HGNC:26398; Q96NN9 476 AIG1 HGNC:21607; Q9NVV5 477 AIM2 HGNC:357; O14862 478 AIMP1 HGNC:10648; Q12904 479 AIMP2 HGNC:20609; Q13155
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX10 1) it promotes AIM2-inflammasome activation by maintaining AIM2 protein stability. 2) it promotes human lung carcinoma
GPATCH2L
Enzyme found in humans
complex cytoplasm cytosol NLRP1 inflammasome complex extracellular region AIM2 inflammasome complex mitochondrion IPAF inflammasome complex protease inhibitor
Caspase_1
Coord Patrol (CORPAT) & 3rd Bilat-Ex betwn IN & Indonesian Navy with an aim2 foster maritime ties with countries located on rim of IORpic.twitter.com/M0nd8cFkdK"
List of Indian Naval deployments
List_of_Indian_Naval_deployments
Enzyme found in humans
component of multiple PANoptosomes, including the ZBP1-PANoptosome and the AIM2-PANoptosome. Additionally, RIPK1 also drives the formation of the RIPK1-PANoptosome
RIPK1
AIM2
AIM2
AIM2
AIM2
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