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ABCB4

ABCB4

Protein-coding gene in humans

The ATP-binding cassette 4 (ABCB4) gene encodes multidrug resistance protein 3. ABCB4 is associated with progressive familial intrahepatic cholestasis

ABCB4

Intrahepatic cholestasis of pregnancy

Medical condition

the disease. Genetic mutations in the hepatocellular transport protein ABCB4 (MDR3), which controls secretion of phosphatidylcholine into bile, have

Intrahepatic cholestasis of pregnancy

Intrahepatic_cholestasis_of_pregnancy

Shetland Sheepdog

Scottish breed of dog

disease in the Shetland Sheepdog found that an insertion mutation of the ABCB4 gene that occurs in the Shetland Sheepdog—as well as other breeds—had a

Shetland Sheepdog

Shetland_Sheepdog

Cholestasis

Medical condition

ABCB11 gene encodes for the bile salt export pump (BSEP) protein, and the ABCB4 gene encodes for the multidrug resistance 3 (MDR3) protein. BSEP and MDR3

Cholestasis

Progressive familial intrahepatic cholestasis

Medical condition

ABCB11 deficiency or BSEP deficiency Type 3 (OMIM #602347), also called ABCB4 deficiency or MDR3 deficiency Type 4 (OMIM #615878), from mutation in TJP2

Progressive familial intrahepatic cholestasis

Progressive_familial_intrahepatic_cholestasis

Canine gallbladder mucocele

Biliary disease in dogs

are also predisposed to developing gallbladder mucoceles as the mutation ABCB4 gene has been associated and these breeds often show signs of lipid metabolism

Canine gallbladder mucocele

Canine_gallbladder_mucocele

ATP-binding domain of ABC transporters

Water-soluble domain of transmembrane ABC transporters

ABCA3; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC2;

ATP-binding domain of ABC transporters

ATP-binding_domain_of_ABC_transporters

ABC transporter

Gene family

ABCB transporters such as ABCB4 participate in both the export and import of auxin At low intracellular auxin concentrations ABCB4 imports auxin until it

ABC transporter

ABC_transporter

Transmembrane domain of ABC transporters

Main transmembrane structural unit of ATP-binding cassette transporter proteins

transporter, permease protein EhuC InterPro: IPR014342 ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13;

Transmembrane domain of ABC transporters

Transmembrane_domain_of_ABC_transporters

List of human protein-coding genes 1

HGNC:14637; Q86UK0 42 ABCA13 HGNC:14638; Q86UQ4 43 ABCB1 HGNC:40; P08183 44 ABCB4 HGNC:45; P21439 45 ABCB5 HGNC:46; Q2M3G0 46 ABCB6 HGNC:47; Q9NP58 47 ABCB7

List of human protein-coding genes 1

List_of_human_protein-coding_genes_1

MDR3

Topics referred to by the same term

Multidrug resistance protein 3, a protein that in humans is encoded by the ABCB4 gene and is associated with progressive familial intrahepatic cholestasis

MDR3

ABCB11

Protein-coding gene in humans

Chiorean E, Krawczyk M, Grünhage F, Lammert F (June 2009). "Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones

ABCB11

List of OMIM disorder codes

243300; ATP8B1 Cholestasis, familial intrahepatic, of pregnancy; 147480; ABCB4 Cholestasis, progressive familial intrahepatic 1; 211600; ATP8B1 Cholestasis

List of OMIM disorder codes

List_of_OMIM_disorder_codes

Piet Borst

Dutch biologist, molecular biologist and biochemist

the gut (oral availability of drugs) (24) (25). Proof that the Mdr2/MDR3 (ABCB4) P-glycoprotein is a phosphatidylcholine translocator, essential for bile

Piet Borst

Piet_Borst