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Spemann–Mangold organizer

region, which will then induce additional transcription factors such as Xnr1, Xnr2, Gsc, chordin (chd). The final cue is mediated by Nodal/activin signaling

Cerberus (protein)

While the increase of just BMP4, Xnr1, Xwnt8 led to defects in the formation of the head. The increase of BMP4, Xnr1, Xwnt8 and the decrease of Cerberus

Kevin Lustig

Marc Kirschner invented a paracrine signaling assay and used it to identify Xnr1, which is part of a cell signaling pathway generating left-right asymmetry

Nodal homolog

asymmetry. Another example of protein speciation is the case of the frog where Xnr1 and Xnr2 regulate movements in gastrulation in contrast to Xnr5 and Xnr6

Regional differentiation

binding to its receptor, Cerberus is also capable of binding to BMP-4 and Xnr1. Furthermore, Dickkopf binds to LRP-5, a transmembrane protein important