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HPV18

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HPV18

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HPV18

Human papillomavirus infection

throat. Nearly all cervical cancer is due to HPV and two strains, HPV16 and HPV18, account for 70% of all cases. HPV16 is responsible for almost 90% of HPV-related

HeLa

and immortality. Horizontal gene transfer from human papillomavirus 18 (HPV18) to human cervical cells created the HeLa genome, which is different from

History of cancer

contaminated by HeLa. In 1984, Harald zur Hausen discovered first HPV16 and then HPV18 responsible for approximately 70% of cervical cancers. For discovery that

Middle ear

papillomavirus infection. Indeed, DNAs belonging to oncogenic HPVs, i.e., HPV16 and HPV18, have been detected in normal middle ear specimens, thereby indicating that

Papillomaviridae

Structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6

Harald zur Hausen

means of Southern blot hybridization. This was followed by the discovery of HPV18 a year later, thus identifying the causes of approximately 75% of human

Oral cancer

suppression and chronic oral graft-versus-host disease. This HPV16 (along with HPV18) is the same virus responsible for the vast majority of all cervical cancers

Oncovirus

1984 and 1986 Harald zur Hausen and Lutz Gissmann discovered HPV16 and HPV18, together these Papillomaviridae viruses (HPV) are responsible for approximately

Lutz Gissmann

Michael Boshart supervised by him) to isolate and characterize HPV16 and HPV18, the two most oncogenic HPV types causing the vast majority of HPV-induced

DLG1

structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6 2i0l: X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6.