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DLX3

DLX3

that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Dlx3 transcription is mediated through

Hair follicle

morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: Alternative mode for Dlx3 induction in mouse keratinocytes". Nucleic Acids

Theria

"Theria-Specific Homeodomain and cis-Regulatory Element Evolution of the Dlx3–4 Bigene Cluster in 12 Different Mammalian Species". Journal of Experimental

Tricho–dento–osseous syndrome

Tennessee, and North Carolina. The cause of this disease is a mutation in the DLX3 (distal-less 3) gene, which controls hair follicle differentiation and induction

List of human transcription factors

ENSG00000115844 Homeodomain Known motif – High-throughput in vitro [143] TAATTR DLX3 ENSG00000064195 Homeodomain Known motif – High-throughput in vitro [144]

DLX gene family

two-gene clusters (bigene clusters) with each other. There are DLX1-DLX2, DLX3-DLX4, DLX5-DLX6 clusters in vertebrates, linked to Hox gene clusters HOXD

Olfactory epithelium

regulated downstream expression of transcription factors, such as Pax6, Dlx3, Sox2, and others, within the presumptive olfactory placode are crucial for

Wiedemann–Rautenstrauch syndrome

cause autosomal-recessive Wiedemann-Rautenstrauch syndrome. Am J Hum Genet "DLX3 distal-less homeobox 3 [Homo sapiens (human)]". Gene - National Center for

Paraspeckle

Dispensable No CPSF6 Dispensable No CPSF7 Important No DAZAP1 Essential Yes DLX3 n.d. Yes EWSR1 Dispensable Yes Yes FAM98A Important Yes FIGN Important Yes

Homeobox

ANTP-like group. Humans have a "distal-less homeobox" family: DLX1, DLX2, DLX3, DLX4, DLX5, and DLX6. Dlx genes are involved in the development of the nervous