What is the meaning of CIAP2. Phrases containing CIAP2
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CIAP2
CIAP2
repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene. cIAP2 is a member of the inhibitor of apoptosis
proteins 1 and 2 (cIAP1, cIAP2) which polyubiquitinate RIPK1 leading to cell survival through downstream NF-kB signalling. cIAP1 and cIAP2 can also be regulated
activated by bacterial peptidoglycans, they oligomerize and recruit cIAP1, cIAP2, TRAF2 and RIP2. This allows cIAP1 mediated ubiquitination of RIP2, which
three copies. The human IAP family consists of 8 members (NAIP, cIAP1, cIAP2, XIAP, Survivin, Bruce/Apollon, ML-IAP/Livin and ILP-2), and IAP homologs
recruiting RIPK1 and TRADD, which recruits TRAF2, cIAP1 and cIAP2, and LUBAC. cIAP1 and cIAP2 are ubiquitin ligases that form K63-linked ubiquitin chains
metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling". Cell Death & Disease. 14 (6): 388. doi:10.1038/s41419-023-05916-8
responsible for binding the BIR3 domains in IAPs like XIAP, cIAP1, and cIAP2 to induce apoptosis, and sometimes, necroptosis. Several of the numerous
Yingqiu Y.; Dicker, David T. (2007). "Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced
proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. BIR domains belong to the zinc-finger
Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL (Nov 2008). "Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating
CIAP2
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CIAP2
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CIAP2
CIAP2
CIAP2
CIAP2
CIAP2