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Chemistry

Brain-derived Neurotrophic Factor

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BDNF

Brain-derived neurotrophic factor

Brain-derived neurotrophic factors (Bdnf), or abrineurin, is a protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin

Tropomyosin receptor kinase B

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type

Neurobiological effects of physical exercise

increased neuron growth, increased neurological activity (e.g., c-Fos and BDNF signaling), improved stress coping, enhanced cognitive control of behavior

Myokine

neurotrophic factor (BDNF) is also a myokine, though BDNF produced by contracting muscle is not released into circulation. Rather, BDNF produced in skeletal

Neuroprotection

exercise. BDNF is produced within the brain, retina, and skeletal muscle. In the aging brain, the balance between proBDNF and mature BDNF is shifted

Neurotrophic factors

not known. Specifically, BDNF promotes survival of dorsal root ganglion neurons. Even when bound to a truncated TrkB, BDNF still shows growth and developmental

Epigenetics of depression

the binding of MeCP2 to BDNF promoter IV. Because MeCP2 can no longer bind to the BDNF promoter and repress transcription, BDNF levels increase and neuronal

Cerebrolysin

brain whose constituents can include brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor

Neurotrophic hypothesis of depression

levels of: BDNF mRNA and BDNF proteins TrkB (receptor for BDNF) CREB (transcription factor which activates BDNF) Individuals with the BDNF Val66Met polymorphism

Epigenetics of bipolar disorder

neuronal implications, such as the BDNF gene and serotonergic genes. The brain-derived neurotrophic factor (BDNF) gene plays a role in the growth, differentiation