In recent times, there is an increased in the number of depressed people. The causes of this rise are varied from social, environmental to economic factors. Generally, depression results in some changes (decreased) in certain chemicals in the brain, mainly serotonin. In order to prevent or treat cases of depression, an attempt must be made to prevent these substances from changing or to replace them in cases where production is said to be insufficient. This is the base of the activity of the drug, Viibryd. Viibryd is one of the best drugs used for many years to prevent and control depressed patients. Viibryd is the brand name for the drug Vilazodone, a drug that is effective in reducing the symptoms of depression. The medication is recommended to be administered following a once daily dosage regimen for about 14 days. Healthcare providers should advice subjects to always take it with food in order to reduce some of its side effects.
People who are taking Monoamine Oxidase Inhibitor (MAOI) such as the antibiotic linezolid should not take Viibryd. Also, Viibryd should not be initiated within 14 days after stopping MAOI and MAOI should not be taken within 14 days after stopping Viibryd.
Functioning and Effectiveness
Viibryd is said to be effective in the treatment of mental health issues that can be classified as major depression disorder (MDD). It is known to work in the brain by stimulating brain cells to production serotonins, the substance that is said to be the main cause of depression. Once Viibryd is administered, it increases Serotonin, which in turns stimulates normal brain functions.
It may take several days, weeks or a few months before your symptoms start improving so keep using the medication as you have been directed and tell your doctor if the symptoms failed to improve or get worse. You should not stop using Viibryd abruptly, else you could have unpleasant withdrawal symptoms. Ask your doctor how you can safely stop using this medicine in case you wish to. Avoid the habit of skipping doses. However, if you miss a dose, you should do well to take it as soon as you remember but you should not double a dose or take it twice in a day.
This medication may affect the way we think or reacts to situations as well as our visual and ability to concentrate. Be careful if you have to drive or do anything that requires you in an alert state.
For best results, patients are required to strictly follow the advice of their doctor.
Before taking Viibryd
Before you start taking Viibryd, you should inform your healthcare provider if:
- · You have a history or have liver, kidney and/or heart problem. Also inform him if you have low sodium levels, seizures, bleeding disorder, drinks alcohol or have any medical condition.
- · You are pregnant, plan to become pregnant, breastfeeding or plan to breastfeed
- · Inform your doctor about all the medicines you are taking including prescription, nonprescription (over the counter) medicines, vitamins and herbal medicines since some medicines may interact with Viibry
- · Make sure you carefully read the medication guide or instruction leaflet that comes with this drug.
Viibryd uses (uses of Viibryd)
Viibryd is a drug used specifically to treat symptoms of major depression disorder. This medicine should not be given to subjects for whom it was not prescribe, even if they have the same symptoms as you. Viibryd may also be used for purposes not listed in this article. You should talk with your healthcare provider about the various uses of Viibryd.
Side Effects of Viibryd
Viibryd is an effective medication against Type 2 diabetes. However, Viibryd use may result in some adverse reaction in some people. These reactions may often be less sever, although there have been some reported cases of increased severity. For these reasons, we are going to group the various side effects of Viibryd based on their severity.
Major (Severe but Less Common) Side Effects of Viibryd
The following symptoms have been associated with severe side effects of Viibryd. If you suspect or notice any, you should discontinue the use of this drug promptly and get an emergency medical help.
· Actions that are out of control
· burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
· trembling or shaking of the hands or feet
- · chest pain or discomfort
- · extra heartbeat
- · fast, irregular, pounding, or racing heartbeat or pulse
- · irritability
- · talking, feeling, and acting with excitement
- · shakiness in the legs, arms, hands, or feet
- · sweating
Minor (Less Severe but Common) Viibryd Side Effects
There are also some less serious but more common Viibryd side effects. These symptoms are often associated with early use of this medication. However, they normally subside as the body adapt to the treatment. Some of these common side effects may include:
- · Abdominal or stomach pain
- · abnormal dreams
- · discomfort in the lower legs
- · acid or sour stomach
- · belching
- · blindness
- · bloated or full feeling
- · difficulty with moving
- · drowsiness
- · dry eyes
- · excess gas in the stomach
- · feeling jittery
- · indigestion
- · relaxed and calm
- · inability to have or keep an erection
- · increased or decreased appetite
- · increased sweating
- · not able to have an orgasm
- · pain in the joints
- · passing gas
- · sleepiness or unusual drowsiness
- · loss in sexual ability, desire, drive, or performance
- · loss of appetite
- · loss of taste
- · muscle pain or stiffness
- · night sweats
- · stomach discomfort or upset
- · unusual tiredness or weakness
- · weakness
- dry mouth
- sensation of crawling in the legs
- Eye painvomiting
- trouble sleeping
- blurr vision
- change in taste
- decreased interest in sexual intercourse
- decreased vision
- headache, severe and throbbing
While this may not be a complete list of all the possible side effects of Viibryd, you may have to consult your healthcare provider about the various Viibryd side effects consistent with your medical record. If you notice any unwanted reaction while using this drug, report it to your doctor. You should talk to your health care provider about the various side effects.
Overdose with Viibryd
There have been some cases of overdose in association with Viibryd reported. These patients are said to show severity of some symptoms associated with the side effects of Viibryd such as anxiety, vomiting and severe nausea. Once overdose is suspected or noticed, you should discontinue Viibryd, and seek immediate medical help. Adequate supportive treatment consistent with the patient’s medical record should be initiated as a means to combat the overdose.
Half-life of Viibryd
Viibryd is eliminated from the body mainly through hepatic metabolism. The rate of metabolism of Vilazodone is increased with the dose and steady-state is achieved in approximately 3 days. The terminal half-life (time for the maximum concentration in the plasma to drop by half) of Viibryd is about 25 hours. Thus, dosage regimen for Viibryd is best suited for once daily administration.
Storage and Handling of Viibryd
Viibryd is best stored at room temperature, 25°C (77°F) with excursions permitted to 15° to 30°C (59° to 86°F). All medicines should be stored in their original packaging in a clean, dry place, away from moisture. Keep medicines away from high temperature, open flames and from direct rays from the sun. Do not use this medicine if found to have expired and dispose of any unused or expired medicines, together with its packs following best environmental practices. Keep all medicines, including Viibryd out of the reach of children and pets.
Warnings and Precautions
Increase in Suicidal Thoughts and Behavior
Viibryd, like most antidepressants to a greater degree increase the risk of people, younger than 24 years who may want to commit suicide. Thus, people undergoing Viibryd therapy should be monitored closely and any symptoms of worsening symptoms or signs of suicidal thoughts and behavior be treated with some urgency.
Viibryd has also been associated with a potentially life-threatening clinical situation known as Serotonin syndrome. The potential risk of developing this condition is said to be increased when this drug is taken together with other serotonergic medicines such as tricyclic antidepressants, amphetamines, fentanyl, and St. John's Wort. Sign and symptoms of Serotonin syndrome include dizziness, agitation, hallucinations, coma, labile blood pressure, seizures, nausea, vomiting, tremor, rigidity, and hyperthermia.
Increased Risk of Bleeding
Drugs, including Viibryd that interfere with the flow of serotonin are said to increase conditions that may lead to bleeding. This risk is further increase in subjects treated with Viibryd in combination with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDS), warfarin, other antiplatelet drugs, and other anticoagulants. All patients due to Viibryd therapy should be educated about these risks, symptoms and the various ways to remedy.
There have been some reports of adverse reactions occurring in subjects after the discontinuation of Viibryd, antidepressant. The potential risk of these undesirable effects is said to increase in patients with sudden or abrupt discontinuation. Some of the symptoms consist of sweating, paresthesia, tremor, confusion, insomnia, seizures, dysphoric mood, irritability, dizziness, tinnitus, hypomania, and agitation. For this reason, discontinuation should be a gradual process that starts by reducing the dose.
Activation of Hypomania (Mania)
Administering Viibryd, antidepressant to patients with bipolar disorder may result in decreased potassium concentration. Thus, before initiating Viibryd therapy, patients should be examined for any family or personal history of bipolar disorder as well as hypomania or mania.
Use in specific populations
The clinical investigation of Viibryd involving pregnant women didn’t involve a satisfactory number of women. Thus, no significant result was recorded to determine the drug-associated for major miscarriages or birth defects. There were some reports suggesting an increase in the number of solemn birth defects such as decreased fetal weight, and prolonged pregnancies reported in animal studies. Most women who stop antidepressant during pregnancy are also said to be at greater risk of a relapse of depression. Viibryd should however be administered once it’s clear that the potential benefits justifies any risk of adverse effect to the fetus.
There is no verified evidence regarding the passing of Viibryd into human milk, its effects on breastfeeding children, or its effects on the quantity or quality of milk produced. Due to the fact that vilazodone is detected in animal milk, and many medicines pass into human milk, and because of the potential risk for Serotonin syndrome, Viibryd should be administered with caution to nursing women. However, the health and developmental benefits of breastfeeding infant should be taken into account along with the potential side effects on the breastfed child from Viibryd and the mother’s clinical need for Viibryd or from the underlying maternal condition.
The safety and effectiveness of Viibryd have not been determined for pediatric patients (patients younger than 18 years of age). Also, studies about the rate of metabolism of Viibryd in pediatric patients have not been performed. There is also high sensitivity of subjects of this age group due to the fact that their organ and systems are not fully mature and because Viibryd increase the risk of suicidal thoughts and behavior, Viibryd is not approved for used in subjects younger than 18 years.
In clinical experiments, there was no significant difference in the safety and effectiveness between patients in this age group (65 years and older) and younger patients. However, due to the susceptibility of patients in the age group to various cardiac, hepatic, and renal problems, dose selection should always begin with the lowest possible effective dose.
There was no significant difference in the frequency of the resulted side effects in clinical studies involving Viibryd with mild to moderate renal impaired patients compared to normal patients. Thus, no dose adjustment may be recommended to subjects with mild and moderate renal impairment.
Studies involving Viibryd did not include an adequate number of patients with mild, moderate or severe hepatic impairment. For this reason, Viibryd may be used with caution in patients with hepatic impairment. There is also no dose of Viibryd recommended for subjects with hepatic impairment.
Customer reviews of Viibryd can be grouped in positive and negative experiences based on the experience of the user. Generally, when a subject’s experience is positive, the subject attests the effectiveness of the drug. With a poor user experience, the patient will only express dissatisfaction.
Positive Viibryd feedbacks
One begins to feel better in just a couple of weeks following Viibryd administration, but more efficient results are obtained after consumption of a full dose.
Viibryds when consumed as prescribed have regained back energy in some patients permitting them to go to the gym after starting Viibryd treatment. As their serotonin levels become increased and normalized, the feeling is fantastic. Obviously, when a user experiences positive changes with a drug they tend to be prescribers, this should not be the case. Each patient has a specific requirement. This implies prescription must be done by a healthcare professional.
Negative Viibryd feedbacks
Some problems experienced by patients after using Viibryd include extreme fatigue, depression, insomnia, difficulties in breathing, low pulse, chest pain, inability to focus. Other users suffered from an anxiety, suicidal feelings and behavior. This has resulted in some patients taking their own life or committing suicide. However, not all drugs are friendly to all users. The experience differs with different persons. A patient upon consuming Viibryd after surgery had the situation worsened.
Only take Viibryd after prescription by competent personnel. This medication should never be shared with others because Viibryd doses may vary from one person to the other. In addition, Viibryd doses can also change from one person to the other.
A Disclaimer: This write-up has the singular purpose which is guidance of patients who have doubts or medical personnel who are undergoing a series of trainings. In this light, no part of this document or the entire document should be used to replace the medical expertise of a doctor, pharmacist or any other health care provider or health care providing institutions.