70+ Side Effects & Uses of LATUDA (lurasidone) (Treatment of Mental Disorder)

By Miriatu

What is Latuda?

Latuda (lurasidone) is used as an antipsychotic drug which works by changing the effects of chemicals in the brain.

Latuda uses (uses of Latuda)

Latuda is used in the treatment schizophrenia in adults and in teenagers who are at least 13 years old.

It is also used to treat some episodes of depression in adults with bipolar disorder (manic depression).

The uses of Latuda (Latuda uses) vary vastly and no one can ever boast of knowing all its uses.

Important information

Latuda is has not yet been approved for use in psychotic conditions related to dementia. Lurasidone may also increase the risk of death in older adults who have dementia-related conditions.

Some young people have thoughts about suicide when they start taking medicine to treat depression. Stay alert to changes in your mood and/or symptoms. You should report any new or worsening symptoms to your doctor.

Before you start taking Latuda, tell your doctor if you have a liver disease, kidney disease, a history of heart attack or stroke, heart disease, high blood pressure, heart rhythm problems, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or  some suicidal thoughts.


Some other medicines can interact with lurasidone and should not be used at the same time. Tell every one of your healthcare providers about all medicines you use now, and any medicine you start and/or stop using.

While you are still taking Latuda, you may be more sensitive to simple temperature extremes such as very hot or cold conditions. You should avoid getting too cold, or becoming overheated and/or dehydrated. Drink a lot of fluids, especially in hot weather and when you are doing exercise. It is very easy to become dangerously overheated and dehydrated while you are taking this medicine.

Latuda may also impair your thinking or reactions so you should be very careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from your sitting or lying position, or you may feel dizzy and eventually fall. Get up relatively slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of Latuda (lurasidone). Stop using this medicine and get to your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, the feeling like you might pass out, confusion, very fast or pounding heartbeats,  tremors, or twitching or uncontrollable movements of the eyes, lips, face, tongue, arms, or legs.

Before taking this medicine

You are advised not use Latuda if you are allergic to lurasidone.

Some other medicines can interact with lurasidone and should not be used at the same time. Your doctor may also need to change your treatment plan if you are using certain other medicines including:

  • antifungal medicine such as the ketoconazole or voriconazole;
  • antibiotics such as clarithromycin or rifampin;
  • antivirals such as ritonavir;
  • St. John's wort; or
  • Any seizure medicine such as carbamazepine or phenytoin.

Latuda has not been approved for use in psychotic conditions related to dementia. Latuda may also increase the risk of death in older adults (geriatric) with dementia-related conditions.

To make sure this medicine is actually safe for you, make sure you tell your doctor if you have ever had:

  • heart disease, high blood pressure;
  • triglycerides (a type of fat in the blood) or high cholesterol;
  • some seizures or epilepsy;
  • a liver or kidney disease;
  • occasional low white blood cell (WBC) counts;
  • diabetes, or any family history of diabetes;
  • some abnormal hormone function tests (thyroid, pituitary gland);
  • breast cancer;
  • acute depression or bipolar disease (unless you are taking Latuda to treat the depressive episodes);
  • suicidal thoughts and/or actions; or
  • Stroke.

Some young people can have thoughts about suicide when first taking medicine to treat depression. Your doctor should always check your progress at regular visits. Your family, friends or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medication during the last 3 months of pregnancy may however cause problems in the newborn, such as some withdrawal symptoms, breathing complications, feeding problems, tremors, fussiness, and limp or stiff muscles. However, you may have some withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. Ifyou do become pregnant while taking Latuda, do not stop taking the drug without your doctor's advice.

If you are pregnant and meet medical experts, your name may be listed on a pregnancy registry (register). This is to keep track of the outcome of the pregnancy and to evaluate any effects of lurasidone on your baby.

It is not yet known whether lurasidone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are also a nursing mother.

Latuda is not yet approved for schizophrenia in anyone who is younger than 13 years old and is not approved for depression in anyone who is younger than 18 years old.

How should I take Latuda?

You should take your Latuda exactly as prescribed by your doctor. Follow all the directions on your prescription label and do not take this medicine in larger or smaller amounts or for longer than recommended period. Use this medicine regularly to get the most benefit (to get the best out of it). Get your prescription refilled before you totally run out of medicine.

Latuda should always be taken with food (at least 350 calories).

While you are using Latuda, you may also need frequent blood tests.

It may take several weeks before your symptoms actually improve. Keep using the medication as has been directed. You should however call your doctor if your symptoms do not improve, or if they get worse while you are still using Latuda.

It is not advisable to stop using Latuda abroptly. Stopping suddenly may cause some other problems (which may be severe Latuda side effects).

Store at normal room temperature away from moisture and heat.

Latuda dosing information (Dosage of Latuda)

Even though we have seen some of the uses of Latuda, the drug cannot perform well if we don’t follow the dosing strictly. The dosage of Latuda is as described below;

Usual Adult Dose for Schizophrenia:

  • Initial dose: 40 mg orally once a day
  • Maintenance dose: 40 to 160 mg orally once a day
  • Maximum dose: 160 mg per day

Take note

  • The Initial dose titration is not needed.
  • This drug should always be taken with food (at least 350 calories); drug exposure is expected to be significantly lower if is not taken with food.
  • Use: For the treatment of schizophrenia.

Usual Adult Dose for Bipolar Disorder:

  • Initial dose: 20 mg orally once a day
  • Maintenance dose: 20 mg to 120 mg orally once in a day
  • Maximum dose: 120 mg per day

Take note

  • the initial dose titration is not needed; this drug (Latuda) should be taken with food (at least 350 calories) drug exposure is expected to be significantly lower if is not taken with food.
  • the initial and maintenance doses are the same for monotherapy and for adjunctive therapy; in monotherapy studies, efficacy in the lower dose range of about 20 to 60 mg per day was, on average, comparable to higher doses of about 80 mg to 120 mg.
  • The efficacy of the treatment of mania has not yet been established.
  • Uses:
    As a monotherapy or an adjunctive therapy with either lithium or valproate for the treatment of major depressive disorder associated with bipolar disorder (bipolar depression).

What happens if I miss a dose?

Patients sometimes get mixed up and may miss their normal dosage of Latuda. However, take the missed dose as soon as you remember. Skip the missed dose especially if it is almost the time for your next scheduled dose. Do not take extra medicine (s) to make up the missed dose (s).

What happens if I overdose?

If this occurs then you should seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while I’m taking Latuda?

It is very easy to become dangerously overheated and dehydrated while you are taking Latuda. Drink plenty of fluids (water and juices), especially in hot weather and times of exercise. You may also be more sensitive to normal temperature extremes (hot or cold).

The grapefruit and grapefruit juice may interact with lurasidone and lead to unwanted side effects of Latuda. Totally avoid the use of grapefruit products while taking Latuda.

Latuda side effects (side effects of Latuda)

We must not be carried away by the outline of Latuda uses to the extent that we ignore other aspects because our negligence in using this drug may lead to severe Latuda side effects. You should get emergency medical help if you have signs of allergic reaction to Latuda: hives; difficulty in breathing; swelling of your tongue, face, lips, and/or throat.

You should do well to report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble in sleeping, or if you have an impulsive feeling, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about committing suicide or hurting yourself.

High doses or long-term use of Latuda can cause some serious movement disorders that may not be reversible. Symptoms of this disorder include certain uncontrollable muscle movements of your lips, face, arms, tongue, eyes, or legs. The longer the time that you take this medicine, the more likely you are to develop this serious movement disorder. The risk of this side effect is actually higher in women and older adults.

Call your doctor at once if you have or notice:

  • irregular menstrual periods or cycle, general breast or vaginal changes, nipple discharges;
  • slight dizziness, fainting, fast or slow heartbeat rates;
  • trouble in swallowing;
  • seizure (convulsions);
  • blood cell disorders - sudden weakness or an ill feeling, fever, chills, sore throat, mouth sores, swollen gums, cough, pain when swallowing anything, skin sores, some cold or flu symptoms, trouble in breathing;
  • high blood sugar – an increased thirst, increased urination rates, hunger, dry mouth, fruity breath odors, drowsiness, dry skin, blurred vision, actual loss of weight; or
  • Severe nervous system reactions - very stiff (rigid) muscles, high fever, sweating, confusion, very fast or uneven heartbeats, tremors, and feeling like you might pass out (lightheadedness).

Common Latuda side effects may include:

  • weight gain;
  • drowsiness;
  • nausea, vomiting;
  • feeling restless and/or being unable to sit still; or
  • Tremors, muscle stiffness, problems with some muscle movement.

For the Consumer

Applies to lurasidone: oral tablet

In addition to its needed or known effects, some other unwanted effects may be caused by lurasidone (the active ingredient contained in Latuda). In an event when any of these side effects do occur, they may require immediate medical attention.

Major Side Effects

You should either check with your doctor or pharmacist immediately if any of these side effects occur when taking lurasidone:

More common:

  • total absence of or decrease in body movement
  • difficulty with swallowing anything
  • drooling
  • inability to sit still (to sit upright)
  • incremental or ratchet-like movement of the muscles
  • loss of body balance control
  • mask-like face
  • muscle discomfort
  • muscle trembling, stiffness or jerking
  • the need to keep moving
  • restlessness
  • rigid or stiff muscles
  • shakiness in the legs, hands, arms, and/or feet
  • shuffling walk
  • slow movements
  • slow reflexes
  • slurred speech
  • stiffness of arms and legs
  • tic-like (jerky) movements of the head, mouth, face, and neck
  • trembling or shaking of the feet or hands
  • twisting movements of the entire body
  • uncontrolled movements, especially of the face, back and neck

Less common:

  • Arm, back, or jaw pains
  • blurred vision
  • burning sensation while urinating
  • changes in the patterns and rhythms of speech
  • chest pain and/or discomfort
  • chills
  • cold sweats
  • confusion
  • convulsions
  • difficult or painful urination
  • difficulty in opening the mouth
  • difficulty while breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting positions
  • fast, pounding, or irregular heartbeat or pulses
  • fixed position of the eyes
  • headache
  • high fever
  • occasional inability to move the eyes
  • inability to speak
  • increased blinking or spasms of the eyelids
  • increased sweating
  • lockjaw
  • the loss of bladder control (frequent urination)
  • muscle spasm, especially of the neck and the back
  • nervousness
  • pale skin
  • pounding sounds in the ears
  • seizures
  • severe stiffness of the muscle
  • severe and/or sudden headache
  • slurred speeches
  • sticking out of the patient’s tongue
  • sweating
  • temporary blindness
  • tiredness
  • troubles with breathing, speaking, or swallowing
  • uncontrolled twisting movements of the arms, neck, trunk, or legs
  • unusual bleedings or bruising
  • unusual facial expressions of the patient
  • unusual felling of tiredness or weakness
  • unusually pale skin (skin dryness)
  • some sudden and severe weakness in the arm, leg or on one side of the body


  • Black, tarry stools
  • bloody urine
  • breast pains or swelling
  • cough
  • dark-colored urine
  • relative decrease in the frequency or amount of urine
  • fever
  • increased thirst
  • large, hive-like swelling on the face, eyelids, throat, hands, legs, lips, tongue, feet, or sex organs
  • loss or lack of appetite
  • lower back pain or side pain
  • muscle cramps or spasms
  • muscle pains or stiffness
  • nausea
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the face, fingers, or the lower legs
  • swollen glands
  • troubled breathing
  • vomiting
  • weight gain (gaining more pounds)

Minor Side Effects

Some of the side effects of Latuda may not need medical attention. As your body tries and adjusts to the medicine during treatment these side effects may go away. Your health care professional or doctor may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the shortlisted side effects continue, are bothersome or if you have any other questions (doubts) about them, check with your health care provider:

More common:

  • Acidic or sour stomach
  • anxiety
  • belching
  • drowsiness
  • dry mouth
  • heartburn
  • hyperventilation
  • indigestion
  • irritability
  • relaxed and calm
  • sleepiness and unusual drowsiness
  • stomach discomforts, upset, or pain
  • trouble sleeping
  • unusually deep sleeping
  • unusually longer periods of sleep

Less common:

  • Abnormal dreams
  • anxiety
  • back pain
  • blurred vision
  • burning feeling (sensation) inside the chest or stomach
  • decreased appetite
  • diarrhea
  • a feeling of constant movement of self or surrounding objects
  • indigestion
  • itching or skin rashes
  • unusual sensation of spinning
  • sweating
  • tenderness in the stomach or abdominal area
  • watering of mouth and drooling as well


  • Decreased interests in sexual intercourse
  • inability to have or even keep an erection
  • loss in sexual ability, drive, desire, and/ or performance
  • occasional unexpected or excess milk flow from the breasts

For Healthcare Professionals

Applies to lurasidone: oral tablet


The most common adverse events that have been noted and reported so far included somnolence, akathisia, extrapyramidal symptoms, and nausea (feeling as to vomit).


Common: Increased weight, increase in appetite, decreased appetite
Frequency not reported: total increase in blood sugar levels

In uncontrollable long-term schizophrenia trials this drug was actually associated with a mean increase in glucose from baseline of 1.8 mg/dL at 24 weeks, 0.8 mg/dL at some 36 weeks, and 2.3 mg/dL at 52 weeks. Similar results were also observed in bipolar depression studies. The proportions of lurasidone-treated patients with a 7% or greater increase in body weight was at 4.8% (compared with 3.3% for placebo). The pooled data from short-term trials showed a mean weight gain of 0.43 kg in the lurasidone-treated patients (compared with the -0.2 kg in placebo).


  • Very common: Nausea
  • Common: Vomiting, salivary hypersecretion, dyspepsia, dry mouth, diarrhea
  • Uncommon: Abdominal pains (stomach ache), and/or diarrhea
  • Rare: Gastritis
  • Frequency not reported: Dysphagia
  • Very common: Somnolence, extrapyramidal disorder, akathisia
  • Common: Dizziness, dystonia
  • Uncommon: Cerebrovascular accidents, dysarthria, seizures
  • Frequency not reported: the neuroleptic malignant syndrome and/or gait disturbance
  • Akathisia and extrapyramidal symptoms were related to dosing.
  • Very common: Insomnia
  • Common: Agitation, restlessness, anxiety
  • Uncommon: Abnormal dreams, panic attacks, catatonia, sleep disorders, suicidal ideation, activation of mania/hypomania
  • Frequency not reported: Panic attacks, disorders in sleeping
  • Uncommon: Anemia
  • Rare: Eosinophilia
  • Frequency not reported: e.g. Leukopenia, and the neutropenia
  • Common: Tachycardia, hypertension
  • Uncommon: AV block 1st degree, angina pectoris, bradycardia, hypotension, or orthostatic hypotension
  • Rare: Syncope
  • Frequency not reported: Bradycardia

Nervous system




In some short-term trials orthostatic hypotension and syncope were reported in 0.3% and 0.1% (n=1508) of patients in the schizophrenia studies. No reports where given in the bipolar depression monotherapy trials. 

ECG measurements that were taken at various points during clinical trials found no QT prolongations exceeding 500 milliseconds (ms) including a subset of patients defined as having an increased cardiac risk. In a dedicated QT study in the clinically stable patients with the schizophrenia or schizoaffective disorder (n=87), the total maximum mean increase in QTc was at  0.36 ms and 1.69 ms for a 120 mg and 600 mg of the dose, respectively. However, no patient experienced a QTc increase of greater than 60 ms from baseline and no patient experienced a QTc greater than 500 ms.


  • Common: Back pains, increased levels of creatinine phosphokinase
  • Uncommon: Joint stiffness, neck pain, or myalgia
  • Rare: Rhabdomyolysis
  • Common: Rash, or pruritus
  • Uncommon: Hyperhidrosis
  • Rare: Angioedema
  • Common: Urinary tract infections
  • Uncommon: Dysuria, dysmenorrhea, and the amenorrhea
  • Rare: Erectile dysfunctions
  • Common: Elevations in serum creatinine
  • Rare: Renal failures





In the schizophrenia studies, the proportion of patients with the prolactin elevations 5 times the upper limit of normal (5 x ULN) or greater was 2.8% compared with 1% in placebo. The proportion of the female patients and male patients with elevations of 5 x ULN or greater was 5.7% and 1.6%, respectively.

  • Common: Elevation in prolactin levels
  • Rare: Breast enlargement, galactorrhea, or breast pain
  • Fatigue
  • Vertigo
  • Sudden death
  • Frequency not reported: A drug withdrawal syndrome which is neonatal

Hepatic: Alanine aminotransferase rates increased

Hypersensitivity: (Postmarketing reports) Hypersensitivity

Immunologic: Influenza

Ocular: Common (1% to 10%): Blurred vision


Respiratory: Nasopharyngitis

In Summary

The Common side effects of Latuda include: psychomotor retardation, akathisia, drowsiness, basal ganglia disease, hypokinesia, muscle rigidity, parkinson's disease, nausea, sedation, tremor, altered serum glucose, bradykinesia, dystonia, torticollis, cogwheel rigidity and drooling. 

Other side effects may include: oculogyric crisis, trismus, agitation, anxiety, increased serum prolactin, and weight gain (growing fatter).

It should be noted that if we disregard the dosage of Latuda, adverse side effects may occur. However, this is not a complete list of side effects and others may occur. Call your doctor for some medical advice about the side effects. You may also the report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Latuda?

Taking Latuda with some other drugs that make you sleepy or reduce your breathing rates can cause dangerous or life-threatening side effects hence you should ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Many other drugs may interact with lurasidone. Not all the possible interactions are listed here so you should tell your doctor about all your current medicines and any you start or stop using, especially medicines used to treat:

  • depression or some psychotic episodes;
  • sleep problems (insomnia);
  • high blood pressure or heart rhythm disorders;
  • swelling and/or inflammation;
  • seizures; or
  • Parkinson's disease.

This list is not a complete one and many other drugs can interact with lurasidone. This includes other prescription and over-the-counter medicines, vitamins, and some other herbal products. You should give a list of all your medicines to any of your healthcare providers who treat you.

Having looked at Latuda uses (uses of Latuda), the dosage of Latuda, side effects and others, we have seen that it is a very dangerous drug and should not be joked with.

A disclaimer: This write-up is just a document that can be used in case of doubts. In case you have a doctor who is treating you, never use the ideas in this write-up to counter his/her own expertise.

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